Rodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorHarvard School of Dental Medicine-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorYale University School of Medicine-
Autor(es): dc.creatorHadad, Henrique-
Autor(es): dc.creatorMatheus, Henrique R.-
Autor(es): dc.creatorPai, Sara I.-
Autor(es): dc.creatorSouza, Francisley A.-
Autor(es): dc.creatorGuastaldi, Fernando P.S.-
Data de aceite: dc.date.accessioned2025-08-21T17:46:32Z-
Data de disponibilização: dc.date.available2025-08-21T17:46:32Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2023.105875-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307211-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307211-
Descrição: dc.descriptionObjective: To assess the outcomes of several rodent animal models for studying tooth extraction-related medication-related osteonecrosis of the jaw (MRONJ). Design: After a search of the databases, 2004 articles were located, and 118 corroborated the inclusion factors (in vivo studies in rodents evaluating tooth extraction as a risk factor for the development of MRONJ). Results: Numerous studies attempting to establish an optimal protocol to induce MRONJ were found. Zoledronic acid (ZA) was the most used drug, followed by alendronate (ALN). Even when ZA did not lead to the development of MRONJ, its effect compromised the homeostasis of the bone and soft tissue. The association of other risk factors (dexamethasone, diabetes, and tooth-related inflammatory dental disease) besides tooth extraction also played a role in the development of MRONJ. In addition, studies demonstrated a relationship between cumulative dose and MRONJ. Conclusions: Both ZA and ALN can lead to MRONJ in rodents when equivalent human doses (in osteoporosis or cancer treatment) are used. Local oral risk factors and tooth-related inflammatory dental disease increase the incidence of MRONJ in a tooth extraction-related rodent model.-
Descrição: dc.descriptionMassachusetts General Hospital-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery Massachusetts General Hospital Harvard School of Dental Medicine-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Oral & Maxillofacial Surgery Division São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Periodontics Division São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Surgery Division of Otolaryngology-Head and Neck Surgery Yale University School of Medicine-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Oral & Maxillofacial Surgery Division São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Periodontics Division São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionFAPESP: 2019/22657-8-
Descrição: dc.descriptionCAPES: 88887.570145/2020–00-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiresorptive-
Palavras-chave: dc.subjectBisphosphonates-
Palavras-chave: dc.subjectBRONJ-
Palavras-chave: dc.subjectMRONJ, ONJ-
Título: dc.titleRodents as an animal model for studying tooth extraction-related medication-related osteonecrosis of the jaw: assessment of outcomes-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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