Acute inhibition of nicotinamide adenine dinucleotide phosphate oxidase in the commissural nucleus of the solitary tract reduces arterial pressure and renal sympathetic nerve activity in renovascular hypertension

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Autor(es): dc.contributorFederal University of Goias-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Melbourne-
Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.creatorMarques, Stefanne M.-
Autor(es): dc.creatorMelo, Mariana R.-
Autor(es): dc.creatorZoccal, Daniel B.-
Autor(es): dc.creatorMenani, José V.-
Autor(es): dc.creatorColombari, Débora S.A.-
Autor(es): dc.creatorFerreira-Neto, Marcos L.-
Autor(es): dc.creatorXavier, Carlos H.-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorPedrino, Gustavo R.-
Data de aceite: dc.date.accessioned2025-08-21T18:17:26Z-
Data de disponibilização: dc.date.available2025-08-21T18:17:26Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1097/HJH.0000000000003516-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307151-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307151-
Descrição: dc.descriptionBackground:A growing body of evidence suggests that oxidative stress plays a role in the pathophysiology of hypertension. However, the involvement of the reactive oxygen species (ROS) in the commissural nucleus of the solitary tract (commNTS) in development the of hypertension remains unclear.Method:We evaluated the hemodynamic and sympathetic responses to acute inhibition of NADPH oxidase in the commNTS in renovascular hypertensive rats. Under anesthesia, male Holtzman rats were implanted with a silver clip around the left renal artery to induce 2-kidney 1-clip (2K1C) hypertension. After six weeks, these rats were anesthetized and instrumented for recording mean arterial pressure (MAP), renal blood flow (RBF), renal vascular resistance (RVR), and renal sympathetic nerve activity (RSNA) during baseline and after injection of apocynin (nicotinamide adenine dinucleotide phosphate oxidase inhibitor), NSC 23766 (RAC inhibitor) or saline into the commNTS.Results:Apocynin into the commNTS decreased MAP, RSNA, and RVR in 2K1C rats. NSC 23766 into the commNTS decreased MAP and RSNA, without changing RVR in 2K1C rats.Conclusion:These results demonstrate that the formation of ROS in the commNTS is important to maintain sympathoexcitation and hypertension in 2K1C rats and suggest that NADPH oxidase in the commNTS could be a potential target for therapeutics in renovascular hypertension.-
Descrição: dc.descriptionCenter for Neuroscience and Cardiovascular Research Federal University of Goias, GO-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology University of Melbourne-
Descrição: dc.descriptionDepartment of Physiology Institute of Biomedical Sciences Federal University of Uberlândia-
Descrição: dc.descriptionSystems Neurobiology Laboratory Department of Physiological Sciences Institute of Biological Science Federal University of Goias, GO-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Formato: dc.format1634-1644-
Idioma: dc.languageen-
Relação: dc.relationJournal of Hypertension-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcommissural nucleus of the solitary tract-
Palavras-chave: dc.subjectneural control of blood pressure-
Palavras-chave: dc.subjectnicotinamide adenine dinucleotide phosphate oxidase inhibitor-
Palavras-chave: dc.subjectreactive oxygen species-
Palavras-chave: dc.subjectrenal vascular resistance-
Título: dc.titleAcute inhibition of nicotinamide adenine dinucleotide phosphate oxidase in the commissural nucleus of the solitary tract reduces arterial pressure and renal sympathetic nerve activity in renovascular hypertension-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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