Maternal high-fat diet changes breathing pattern and causes excessive sympathetic discharge in juvenile offspring rat

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorKarlen-Amarante, Marlusa-
Autor(es): dc.creatorBassi, Mirian-
Autor(es): dc.creatorBarbosa, Rafaela Moreira-
Autor(es): dc.creatorSá, Jessica Matheus-
Autor(es): dc.creatorMenani, Jose Vanderlei-
Autor(es): dc.creatorColombari, Eduardo-
Autor(es): dc.creatorZoccal, Daniel B.-
Autor(es): dc.creatorColombari, Debora Simões Almeida-
Data de aceite: dc.date.accessioned2025-08-21T21:00:51Z-
Data de disponibilização: dc.date.available2025-08-21T21:00:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/ajplung.00013.2023-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/307006-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/307006-
Descrição: dc.descriptionEarly life over-nutrition, as experienced in maternal obesity, is a risk factor for developing cardiorespiratory and metabolic diseases. Here we investigated the effects of high-fat diet (HFD) consumption on the breathing pattern and sympathetic discharge to blood vessels in juvenile offspring from dams fed with HFD (O-HFD). Adult female Holtzman rats were given a standard diet (SD) or HFD from 6 wk before gestation to weaning. At weaning (P21), the male offspring from SD dams (O-SD) and O-HFD received SD until the experimental day (P28-P45). Nerve recordings performed in decerebrated in situ preparations demonstrated that O-HFD animals presented abdominal expiratory hyperactivity under resting conditions and higher vasoconstrictor sympathetic activity levels. The latter was associated with blunted respiratory-related oscillations in sympathetic activity, especially in control animals. When exposed to elevated hypercapnia or hypoxia levels, the O-HFD animals mounted similar ventilatory and respiratory motor responses as the control animals. Hypercapnia and hypoxia exposure also increased sympathetic activity in both groups but did not reinstate the respiratory-sympathetic coupling in the O-HFD rats. In freely behaving conditions, O-HFD animals exhibited higher resting pulmonary ventilation and larger variability of arterial pressure levels than the O-SD animals due to augmented sympathetic modulation of blood vessel diameter. Maternal obesity modified the functioning of cardiorespiratory systems in offspring at a young age, inducing active expiration and sympathetic overactivity under resting conditions. These observations represent new evidence about pregnancy-related complications that lead to the development of respiratory distress and hypertension in children of obese mothers.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physiology and Pathology School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: 303481/2021-8-
Descrição: dc.descriptionCNPq: 308099/2017-6-
Descrição: dc.descriptionCNPq: 317348/2021-3-
Descrição: dc.descriptionCNPq: 425586/2016-2-
Formato: dc.formatL662-L674-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Lung Cellular and Molecular Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectactive expiration-
Palavras-chave: dc.subjectbreathing-
Palavras-chave: dc.subjecthigh-fat diet-
Palavras-chave: dc.subjectoffspring-
Palavras-chave: dc.subjectsympathetic nerve activity-
Título: dc.titleMaternal high-fat diet changes breathing pattern and causes excessive sympathetic discharge in juvenile offspring rat-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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