Atraumatic restorative treatment induces transient changes in salivary total protein and redox biomarkers in children with caries: A non-randomized clinical study

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.creatorLopes, Adrielle Ouchi-
Autor(es): dc.creatorde Freitas, Rayara Nogueira-
Autor(es): dc.creatorFiais, Gabriela Alice-
Autor(es): dc.creatorHorta, Haylla de Faria-
Autor(es): dc.creatorMateus, Alanna Ramalho-
Autor(es): dc.creatorAraujo, Heitor Ceolin-
Autor(es): dc.creatorAranega, Alessandra Marcondes-
Autor(es): dc.creatorDíaz-Fabregat, Beatriz-
Autor(es): dc.creatorChaves-Neto, Antonio Hernandes-
Autor(es): dc.creatorAntoniali, Cristina-
Data de aceite: dc.date.accessioned2025-08-21T15:21:03Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jdent.2024.105521-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306975-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306975-
Descrição: dc.descriptionAim: This study aimed to evaluate if dental atraumatic restorative treatment (ART) impacts salivary total protein and redox biomarkers in children with caries. Methods: The study included 30 children (aged 4 to 6 years) with caries on posterior deciduous teeth, classified by ICCMS, attending a basic education school. Participants were divided into enamel (n = 15) and dentin (n = 15) lesion groups. Unstimulated saliva samples were collected before (B), immediately after (A), and seven days after (A7) ART. Analyses included total protein concentration, lipid peroxidation (TBARS), total antioxidant capacity (TAC), and uric acid (UA). The results obtained at different time points (B, A, A7) were compared between children with caries and between those with enamel or dentin lesions using a paired repeated-measures ANOVA, followed by Tukey's post-hoc test (p < 0.05). Results: ART caused significant decreases in total protein concentration (p = 0.0146), which rebounded by the 7th day. TBARS levels increased (p = 0.0215) immediately after ART and remained unchanged until the 7th day. TAC (p = 0.0032) and UA (p = 0.0006) levels decreased in the saliva of children 7 days after ART. These changes were significant only in children with dentin lesions, not enamel lesions. Conclusion: ART temporarily alters salivary protein levels and redox biomarkers in children with caries, returning to baseline after 7 days. These findings highlight the importance of complementing restorative treatments with dietary advice and oral hygiene to ensure comprehensive caries management.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionGraduate Program in Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Diagnostics and Surgery São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionGraduate Program in Dentistry University of Western São Paulo (UNOESTE), SP-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionGraduate Program in Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionMulticenter Graduate Program in Physiological Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Diagnostics and Surgery São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dentistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiomarkers-
Palavras-chave: dc.subjectDental atraumatic restorative treatment-
Palavras-chave: dc.subjectDental caries-
Palavras-chave: dc.subjectOxidative stress-
Palavras-chave: dc.subjectSaliva-
Título: dc.titleAtraumatic restorative treatment induces transient changes in salivary total protein and redox biomarkers in children with caries: A non-randomized clinical study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.