Development of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorTechnological Institute of Aeronautics (ITA)-
Autor(es): dc.creatordos Santos, Verônica Ribeiro-
Autor(es): dc.creatorCampos, Tiago Moreira Bastos-
Autor(es): dc.creatorAnselmi, Caroline-
Autor(es): dc.creatorde Souza, Joyce Rodrigues-
Autor(es): dc.creatorLemes, Ana Paula-
Autor(es): dc.creatorThim, Gilmar Patrocínio-
Autor(es): dc.creatorBottino, Marco Cicero-
Autor(es): dc.creatorBorges, Alexandre Luiz Souto-
Autor(es): dc.creatorde Sousa Trichês, Eliandra-
Data de aceite: dc.date.accessioned2025-08-21T16:59:57Z-
Data de disponibilização: dc.date.available2025-08-21T16:59:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jbm.b.35459-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306972-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306972-
Descrição: dc.descriptionPoly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanofibers embedded with borate glasses of 45B5 composition doped with Co2+, Cu2+, and Zn2+(46.1 B─O3-26.9-X CaO-24.4 Na─O-2.6 P─Os, X CoO/CuO/ZnO mol % (X = 0–5)) were produced by electrospinning for wound healing applications. Prior to their addition, the glasses exhibited two broad halos typical of a vitreous borate network, which were mainly composed of ring-type metaborate structural units. The particle distribution in the PHBV nanofibers embedded with 45B5 borate bioactive glasses is present in isolated and agglomerated states, being partially coated by a polymeric layer—except for the cobalt-doped glass, which resulted in a successful encapsulation with 100% embedding efficiency. The incorporation of the glasses reduced the PHBV crystallinity degree and its decomposition temperature, as well as its mechanical properties, including Young's modulus, tensile strength, and elongation at break. The neat PHBV fibers and those containing the cobalt-doped glasses demonstrated great cytocompatibility with human keratinocytes (HaCat), as suggested by the high cell viability after 7 days of exposure. Further studies are needed to fully understand the wound healing potential of these fibers, but our results significantly contribute to the area.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitute of Science and Technology Bioceramics Laboratory Federal University of São Paulo, São Paulo-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology University of São Paulo Bauru School of Dentistry, São Paulo-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Science and Technology Department of Dental Materials and Prosthodontics São Paulo State University-
Descrição: dc.descriptionInstitute of Science and Technology Polymers and Biopolymers Technology Laboratory Federal University of São Paulo, São Paulo-
Descrição: dc.descriptionLaboratory of Plasma and Processes (LPP) Technological Institute of Aeronautics (ITA), São Paulo-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan-
Descrição: dc.descriptionDepartment of Morphology and Pediatric Dentistry School of Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionInstitute of Science and Technology Department of Dental Materials and Prosthodontics São Paulo State University-
Descrição: dc.descriptionFAPESP: 20/12507-6-
Descrição: dc.descriptionFAPESP: 20/12874-9-
Descrição: dc.descriptionFAPESP: 2019/10877-3-
Descrição: dc.descriptionFAPESP: 2019/19594-4-
Descrição: dc.descriptionFAPESP: 2022/12217-3-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biomedical Materials Research - Part B Applied Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectborate bioactive glass-
Palavras-chave: dc.subjectcytocompatibility-
Palavras-chave: dc.subjectelectrospinning-
Palavras-chave: dc.subjectnanofiber-
Palavras-chave: dc.subjectPHBV-
Palavras-chave: dc.subjectwound dressing-
Título: dc.titleDevelopment of PHBV electrospun fibers containing a borate bioactive glass doped with Co, Cu, and Zn for wound dressings-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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