Antimicrobial effect of silver nanoparticles as a potential healing treatment for wounds contaminated with Staphylococcus aureus in wistar rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Araraquara-
Autor(es): dc.contributorUniversity Center of Herminio Ometto Foundation-FHO. Maximiliano Baruto-
Autor(es): dc.creatorBaveloni, Franciele Garcia-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorSábio, Rafael Miguel-
Autor(es): dc.creatorCamargo, Bruna Almeida Furquim de-
Autor(es): dc.creatorTrevisan, Débora Pizzaia Vaccari-
Autor(es): dc.creatorDuarte, Jonatas Lobato-
Autor(es): dc.creatorAraújo, Jennifer Thayanne Cavalcante de-
Autor(es): dc.creatorLuiz, Marcela Tavares-
Autor(es): dc.creatorZanatta, Melina Borges Teixeira-
Autor(es): dc.creatorSilva, Isabella Carvalho Pereira da-
Autor(es): dc.creatorBarud, Hernane-
Autor(es): dc.creatorAndrade, Thiago Antônio Moretti de-
Autor(es): dc.creatorMenegário, Amauri Antônio-
Autor(es): dc.creatorBauab, Taís Maria-
Autor(es): dc.creatorChorilli, Marlus-
Data de aceite: dc.date.accessioned2025-08-21T20:16:29Z-
Data de disponibilização: dc.date.available2025-08-21T20:16:29Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jddst.2024.106445-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306938-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306938-
Descrição: dc.descriptionCurrently, the main challenges associated with conventional treatments for complex wounds include antibiotic resistance, persistent infections, delayed healing, pain and discomfort, lesion recurrence, and limited patient adherence. Silver nanoparticles (AgNPs) have demonstrated potential for bacterial control in contaminated wounds while promoting tissue regeneration. The aim of this study was to evaluate the bactericidal activity of AgNPs in wounds contaminated and non-contaminated with S. aureus. An aqueous suspension of AgNPs at a concentration of 117 μg/mL was synthesized by reducing silver nitrate in a medium containing tannic acid and sodium citrate. The resulting nanoparticles were spherical, with an average diameter of 24.3 ± 0.18 nm, a polydispersity index (PDI) of 0.25 ± 0.013, and a ζ-potential of −60.0 ± 3.07 mV. The bactericidal effect of AgNPs was observed at concentrations of 58.5 μg/mL for Escherichia coli and 6.74 μg/mL for S. aureus and Pseudomonas aeruginosa. Fibroblast viability (L929 cells) was maintained at confluence with AgNPs concentrations ranging from 0.1 μg/mL to 7.3 μg/mL. On the 7th day post-wound induction, animals treated with AgNPs exhibited 90 % re-epithelialization along with effective microbiological control. Histological analysis revealed a significant increase in fibroblast production in the treated groups compared to controls (p < 0.01). These results indicate that AgNPs hold promise for topical applications in bacterial control and wound healing.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Drugs and Medicines São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionSão Paulo State University - UNESP Center for Environmental Studies, São Paulo-
Descrição: dc.descriptionLaboratory of Biopolymers and Biomaterials University of Araraquara, São Paulo-
Descrição: dc.descriptionGraduate Program in Biomedical Sciences University Center of Herminio Ometto Foundation-FHO. Maximiliano Baruto, São Paulo-
Descrição: dc.descriptionDepartment of Drugs and Medicines São Paulo State University “Júlio de Mesquita Filho”, São Paulo-
Descrição: dc.descriptionSão Paulo State University - UNESP Center for Environmental Studies, São Paulo-
Descrição: dc.descriptionCAPES: 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Drug Delivery Science and Technology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibacterial effect-
Palavras-chave: dc.subjectSilver nanoparticles-
Palavras-chave: dc.subjectSynthesis-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleAntimicrobial effect of silver nanoparticles as a potential healing treatment for wounds contaminated with Staphylococcus aureus in wistar rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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