Synergistic effect of the verapamil and amphotericin B against Cryptococcus neoformans

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFundação Oswaldo Cruz (Fiocruz)-
Autor(es): dc.contributorPrograma de Pós-Graduação em Enfermagem-
Autor(es): dc.creatorPereira, Thaís C.-
Autor(es): dc.creatordo Carmo, Paulo H. F.-
Autor(es): dc.creatorde Menezes, Raquel T.-
Autor(es): dc.creatorde Oliveira, Haroldo C.-
Autor(es): dc.creatorde Oliveira, Luciane D.-
Autor(es): dc.creatorJunqueira, Juliana C.-
Autor(es): dc.creatorScorzoni, Liliana-
Data de aceite: dc.date.accessioned2025-08-21T23:45:09Z-
Data de disponibilização: dc.date.available2025-08-21T23:45:09Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12223-023-01104-5-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306915-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306915-
Descrição: dc.descriptionCryptococcus neoformans is an encapsulated yeast that can cause cryptococcosis and cryptococcal meningitis, which conventional treatment involves antifungal drugs such as polyenes, flucytosine, azoles, and their combinations. However, the high cost, toxicity, and increase in fungi resistance to antifungal agents stimulate the search for therapeutic strategies such as drug repurposing and combination therapy. This study evaluated the activity of the antihypertensive verapamil (VEH) alone and combined with amphotericin B (AmB) against C. neoformans. VEH exhibited antifungal activity against C. neoformans with minimum inhibitory concentration and minimum fungicidal concentration of 118 µg per mL. The combination of VEH and AmB exhibited synergism, reducing at least eightfold both drugs’ concentrations. Moreover, the combination decreased the size and glucuronoxylomannnan content of C. neoformans capsule. However, no difference was observed in ergosterol levels of C. neoformans after treatment with VEH and AmB in combination. Altogether, VEH in combination with AmB exhibits potential as a candidate as for the development of anti-cryptococcal drug.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionInstituto Carlos Chagas Fundação Oswaldo Cruz (Fiocruz)-
Descrição: dc.descriptionUniversidade de Guarulhos (UNG) Programa de Pós-Graduação em Enfermagem, SP-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Formato: dc.format999-1004-
Idioma: dc.languageen-
Relação: dc.relationFolia Microbiologica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntifungal-
Palavras-chave: dc.subjectCapsule-
Palavras-chave: dc.subjectCryptococcus neoformans-
Palavras-chave: dc.subjectSynergism-
Palavras-chave: dc.subjectVerapamil-
Título: dc.titleSynergistic effect of the verapamil and amphotericin B against Cryptococcus neoformans-
Tipo de arquivo: dc.typelivro digital-
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