Mild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level— an observational sub-analysis fit- COVID study

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCoimbra Health School-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorCentral Washington University-
Autor(es): dc.contributorUniversidade do Oeste Paulista (UNOESTE)-
Autor(es): dc.contributorFederal University of Health Sciences of Porto Alegre-
Autor(es): dc.contributorPontifícia Universidade Católica do Parana-
Autor(es): dc.contributorUniversity of British Columbia-
Autor(es): dc.contributorJustus-Liebig-University Giessen-
Autor(es): dc.contributorUniversidade de Coimbra-
Autor(es): dc.creatorSilva, Bruna Spolador de Alencar-
Autor(es): dc.creatorPereira, Telmo-
Autor(es): dc.creatorMinuzzi, Luciele Guerra-
Autor(es): dc.creatorPadilha, Camila Souza-
Autor(es): dc.creatorFigueiredo, Caique-
Autor(es): dc.creatorOlean-Oliveira, Tiago-
Autor(es): dc.creatordos Santos, Ivete Vera Medeiros-
Autor(es): dc.creatorvon Ah Morano, Ana Elisa-
Autor(es): dc.creatorMarchioto Júnior, Osmar-
Autor(es): dc.creatorRibeiro, José Procópio Jabur-
Autor(es): dc.creatorDos Santos, Vanessa Ribeiro-
Autor(es): dc.creatorSeelaender, Marília-
Autor(es): dc.creatorTeixeira, Alexandre Abílio-
Autor(es): dc.creatorDos Santos, Ronaldo Vagner T.-
Autor(es): dc.creatorLemos, Valdir de Aquino-
Autor(es): dc.creatorFreire, Ana Paula Coelho Figueira-
Autor(es): dc.creatorDorneles, Gilson Pires-
Autor(es): dc.creatorMarmett, Bruna-
Autor(es): dc.creatorOlean-Oliveira, André-
Autor(es): dc.creatorTeixeira, Marcos F. S.-
Autor(es): dc.creatorSeraphim, Patrícia M.-
Autor(es): dc.creatorCaseiro, Armando-
Autor(es): dc.creatorPinho, Ricardo Aurino-
Autor(es): dc.creatorIslam, Hashim-
Autor(es): dc.creatorLittle, Jonathan Peter-
Autor(es): dc.creatorKrüger, Karsten-
Autor(es): dc.creatorRosa-Neto, José César-
Autor(es): dc.creatorCoelho-E-Silva, Manuel-João-
Autor(es): dc.creatorLira, Fábio Santos-
Data de aceite: dc.date.accessioned2025-08-21T20:45:20Z-
Data de disponibilização: dc.date.available2025-08-21T20:45:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fimmu.2023.1212745-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306906-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306906-
Descrição: dc.descriptionAim: This study aimed to evaluate if physical activity is associated with systemic and cellular immunometabolic responses, in young adults after mild-to-moderate COVID-19 infection. Methods: Mild- to- moderate post-COVID-19 patients (70.50 ± 43.10 days of diagnosis; age: 29.4 (21.9– 34.9) years; BMI: 25.5 ± 4.3 kg m2 n = 20) and healthy age-matched controls (age: 29.3 (21.2 – 32.6) years; BMI: 25.4 ± 4.7 kg m2; n = 20) were evaluated. Physical activity levels (PAL), body composition, dietary habits, muscular and pulmonary function, mental health, sleep quality, metabolic parameters, immune phenotypic characterization, stimulated whole blood and PBMC culture (cytokine production), mRNA, and mitochondrial respiration in PBMCs were evaluated. Results: The post-COVID-19 group exhibited lower levels of moderate to vigorous physical activity (MVPA) (p = 0.038); therefore, all study comparisons were performed with adjustment for MVPA. Post-COVID-19 impacted the pulmonary function (FEV1, FEV1%pred, FVC, and FVC %pred) compared with the control (p adjusted by MVPA (p adj) <0.05). Post-COVID-19 exhibited lower levels of serum IL-6 (p adj <0.01), whereas it showed higher serum IL-10, triglyceride, leptin, IgG, ACE activity, TNFRSF1A, and PGE2 (p adj <0.05) levels compared with controls. Post-COVID-19 presented a lower percentage of Treg cells (p adj = 0.03) and altered markers of lymphocyte activation and exhaustion (lower CD28 expression in CD8+ T cells (p adj = 0.014), whereas CD4+T cells showed higher PD1 expression (p adj = 0.037)) compared with the control group. Finally, post- COVID-19 presented an increased LPS-stimulated whole- blood IL-10 concentration (p adj <0.01). When exploring mitochondrial respiration and gene expression in PBMCs, we observed a higher LEAK state value (p adj <0.01), lower OXPHOS activity (complex I) (p adj = 0.04), and expression of the Rev-Erb-α clock mRNA after LPS stimulation in the post-COVID-19 patients than in the control (p adj <0.01). Mainly, PAL was associated with changes in IL-10, triglyceride, and leptin levels in the plasma of post-COVID-19 patients. PAL was also associated with modulation of the peripheral frequency of Treg cells and the expression of PD-1 in CD8+ T cells, although it abrogated the statistical effect in the analysis of TNF-α and IL-6 production by LPS- and PMA-stimulated PBMC of post-COVID-19 patients. Conclusion: Young adults after mild-to-moderate SARS-CoV-2 infection appeared to have lower physical activity levels, which can be associated with clinical and immunometabolic responses in a complex manner.-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionPolytechnic Institute of Coimbra Coimbra Health School-
Descrição: dc.descriptionPostgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCancer Metabolism Research Group LIM26-HC FMUSP Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Cell and Developmental Biology University of São Paulo-
Descrição: dc.descriptionDepartment of Biosciences Universidade Federal de São Paulo (UNIFESP)-
Descrição: dc.descriptionDepartment of Health Sciences Central Washington University-
Descrição: dc.descriptionPhysiotherapy Department Universidade do Oeste Paulista (UNOESTE)-
Descrição: dc.descriptionLaboratory of Cellular and Molecular Immunology Graduate Program in Health Sciences Federal University of Health Sciences of Porto Alegre-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry School of Science and Technology Universidade Estadual Paulista (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Health Sciences School of Medicine Pontifícia Universidade Católica do Parana-
Descrição: dc.descriptionSchool of Health and Exercise Sciences University of British Columbia-
Descrição: dc.descriptionDepartment of Exercise Physiology and Sports Therapy Institute of Sports Science Justus-Liebig-University Giessen-
Descrição: dc.descriptionFaculty of Sport Sciences and Physical Education Research Center for Sport and Physical Activity (uid/dtp/04213/2020) Universidade de Coimbra-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionPostgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionDepartment of Chemistry and Biochemistry School of Science and Technology Universidade Estadual Paulista (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectimmune response-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmetabolism-
Palavras-chave: dc.subjectphysical activity-
Palavras-chave: dc.subjectpost-acute COVID-19 syndrome-
Palavras-chave: dc.subjectSARS-CoV-2-
Título: dc.titleMild to moderate post-COVID-19 alters markers of lymphocyte activation, exhaustion, and immunometabolic responses that can be partially associated by physical activity level— an observational sub-analysis fit- COVID study-
Tipo de arquivo: dc.typelivro digital-
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