Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury

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Autor(es): dc.contributorUniversity of Colorado-
Autor(es): dc.contributorUniversity of Texas MD Anderson Cancer Center-
Autor(es): dc.contributorMD Anderson Pain Research Consortium-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGreen-Fulgham, Suzanne M.-
Autor(es): dc.creatorLacagnina, Michael J.-
Autor(es): dc.creatorWillcox, Kendal F.-
Autor(es): dc.creatorLi, Jiahe-
Autor(es): dc.creatorHarland, Michael E.-
Autor(es): dc.creatorCiena, Adriano Polican-
Autor(es): dc.creatorRocha, Igor R. Correia-
Autor(es): dc.creatorBall, Jayson B.-
Autor(es): dc.creatorDreher, Renee A.-
Autor(es): dc.creatorZuberi, Younus A.-
Autor(es): dc.creatorDragavon, Joseph M.-
Autor(es): dc.creatorChacur, Marucia-
Autor(es): dc.creatorMaier, Steven F.-
Autor(es): dc.creatorWatkins, Linda R.-
Autor(es): dc.creatorGrace, Peter M.-
Data de aceite: dc.date.accessioned2025-08-21T18:02:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:02:46Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbi.2023.10.027-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306897-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306897-
Descrição: dc.descriptionRegular aerobic activity is associated with a reduced risk of chronic pain in humans and rodents. Our previous studies in rodents have shown that prior voluntary wheel running can normalize redox signaling at the site of peripheral nerve injury, attenuating subsequent neuropathic pain. However, the full extent of neuroprotection offered by voluntary wheel running after peripheral nerve injury is unknown. Here, we show that six weeks of voluntary wheel running prior to chronic constriction injury (CCI) reduced the terminal complement membrane attack complex (MAC) at the sciatic nerve injury site. This was associated with increased expression of the MAC inhibitor CD59. The levels of upstream complement components (C3) and their inhibitors (CD55, CR1 and CFH) were altered by CCI, but not increased by voluntary wheel running. Since MAC can degrade myelin, which in turn contributes to neuropathic pain, we evaluated myelin integrity at the sciatic nerve injury site. We found that the loss of myelinated fibers and decreased myelin protein which occurs in sedentary rats following CCI was not observed in rats with prior running. Substitution of prior voluntary wheel running with exogenous CD59 also attenuated mechanical allodynia and reduced MAC deposition at the nerve injury site, pointing to CD59 as a critical effector of the neuroprotective and antinociceptive actions of prior voluntary wheel running. This study links attenuation of neuropathic pain by prior voluntary wheel running with inhibition of MAC and preservation of myelin integrity at the sciatic nerve injury site.-
Descrição: dc.descriptionDepartment of Psychology and Neuroscience and the Center for Neuroscience University of Colorado-
Descrição: dc.descriptionLaboratories of Neuroimmunology Department of Symptom Research University of Texas MD Anderson Cancer Center-
Descrição: dc.descriptionMD Anderson Pain Research Consortium-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionLaboratory of Neuroanatomy Functional of Pain Departamento de Anatomia Instituto de Ciências Biomédicas Universidade de São Paulo-
Descrição: dc.descriptionAdvanced Light Microscopy Core BioFrontiers Institute University of Colorado-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), São Paulo-
Formato: dc.format419-431-
Idioma: dc.languageen-
Relação: dc.relationBrain, Behavior, and Immunity-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCD59-
Palavras-chave: dc.subjectChronic pain-
Palavras-chave: dc.subjectComplement-
Palavras-chave: dc.subjectDemyelination-
Palavras-chave: dc.subjectSciatic nerve-
Título: dc.titleVoluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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