Regenerative and translational medicine in COPD: hype and hope

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorParanaense University (UNIPAR)-
Autor(es): dc.contributorFederal University of Amazonas (UFAM)-
Autor(es): dc.contributorUniversity of Western São Paulo (UNOESTE)-
Autor(es): dc.contributorTechLife-
Autor(es): dc.creatorGuarnier, Lucas Pires-
Autor(es): dc.creatorMoro, Lincoln Gozzi-
Autor(es): dc.creatorDos Reis Lívero, Francislaine Aparecida-
Autor(es): dc.creatorde Faria, Carolina Arruda-
Autor(es): dc.creatorAzevedo, Mauricio Fogaça-
Autor(es): dc.creatorRoma, Beatriz Pizoni-
Autor(es): dc.creatorAlbuquerque, Edilson Rodrigues-
Autor(es): dc.creatorMalagutti-Ferreira, Maria José-
Autor(es): dc.creatorRodrigues, Alessandra Gomes Duarte-
Autor(es): dc.creatorda Silva, Adelson Alves-
Autor(es): dc.creatorSekiya, Eliseo Joji-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T16:24:07Z-
Data de disponibilização: dc.date.available2025-08-21T16:24:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1183/16000617.0223-2022-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306893-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306893-
Descrição: dc.descriptionCOPD is a common, preventable and usually progressive disease associated with an enhanced chronic inflammatory response in the airways and lung, generally caused by exposure to noxious particles and gases. It is a treatable disease characterised by persistent respiratory symptoms and airflow limitation due to abnormalities in the airways and/or alveoli. COPD is currently the third leading cause of death worldwide, representing a serious public health problem and a high social and economic burden. Despite significant advances, effective clinical treatments have not yet been achieved. In this scenario, cell-based therapies have emerged as potentially promising therapeutic approaches. However, there are only a few published studies of cell-based therapies in human patients with COPD and a small number of ongoing clinical trials registered on clinicaltrials.gov. Despite the advances and interesting results, numerous doubts and questions remain about efficacy, mechanisms of action, culture conditions, doses, timing, route of administration and conditions related to homing and engraftment of the infused cells. This article presents the state of the art of cell-based therapy in COPD. Clinical trials that have already been completed and with published results are discussed in detail. We also discuss the questions that remain unanswered about cell-based regenerative and translational medicine for COPD.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy – GenTe Cel Department of Biotechnology São Paulo State University (UNESP)-
Descrição: dc.descriptionBiomedical Sciences Institute Butantan Institute Technological Research Institute University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Paranaense University (UNIPAR)-
Descrição: dc.descriptionHealth and Biotechnology Institute Federal University of Amazonas (UFAM)-
Descrição: dc.descriptionFaculty of Health Sciences University of Western São Paulo (UNOESTE)-
Descrição: dc.descriptionSão Lucas Research and Education Institute (IEP-São Lucas) TechLife-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy – GenTe Cel Department of Biotechnology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationEuropean Respiratory Review-
???dc.source???: dc.sourceScopus-
Título: dc.titleRegenerative and translational medicine in COPD: hype and hope-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.