Gastric plication surgery changes gastrointestinal and metabolic parameters in an obesity-induced high-fat diet model

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAraguaia Valley University Center (UNIVAR)-
Autor(es): dc.contributorFederal University of Mato Grosso (UFMT)-
Autor(es): dc.creatorMachado, Mariana Pirani Rocha-
Autor(es): dc.creatorGama, Loyane Almeida-
Autor(es): dc.creatorBeckmann, Ana Paula S.-
Autor(es): dc.creatorPinto, Leonardo Antônio-
Autor(es): dc.creatorde Miranda, José Ricardo de Arruda-
Autor(es): dc.creatorMarques, Rozemeire Garcia-
Autor(es): dc.creatorAmérico, Madileine Francely-
Data de aceite: dc.date.accessioned2025-08-21T15:51:55Z-
Data de disponibilização: dc.date.available2025-08-21T15:51:55Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/nmo.14717-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306864-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306864-
Descrição: dc.descriptionBackground: Obesity treatment includes less invasive procedures such as gastric plication (GP) surgery; however, its effects on gastrointestinal (GI) motility parameters are underestimated. We aimed to verify the metabolic and gastrointestinal effects of GP surgery in the rat obesity model. Methods: A high-fat diet-induced obesity was used. Animals were allocated to four experimental groups: control sham (n = 6); control GP (n = 10); obese sham (n = 6); and obese GP (n = 10). Nutritional and murinometric parameters, gastric motility, glucose tolerance, histopathology, fat depots, leptin, and lipoproteins levels were evaluated 30 days after surgery. Data were analyzed by ANOVA followed by post Tukey or Kruskal–Wallis test followed by Dunn's multiple comparisons test. Key Results: Gastric plication decreased leptin levels, feed efficiency, and body weight gain. GP does not improve lipid profile in obese animals and however, ameliorates glucose tolerance in control and obese rats. GP did not improve the gastric emptying time or normalize the frequency of contractions disturbed by obesity. Surgery provides a remodeling process in the mucosa and muscularis mucosa layers, evidenced by leukocyte infiltration mainly in the mucosa layer. Conclusions & Inferences: Our study revealed the influence of the gastrointestinal tract on obesity is underestimated with pieces of evidence pointing out its important role as a target for surgical treatment.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionSão Paulo State University – UNESP-
Descrição: dc.descriptionAraguaia Valley University Center (UNIVAR)-
Descrição: dc.descriptionFederal University of Mato Grosso (UFMT)-
Descrição: dc.descriptionSão Paulo State University – UNESP-
Idioma: dc.languageen-
Relação: dc.relationNeurogastroenterology and Motility-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbariatric surgery-
Palavras-chave: dc.subjectgastrointestinal tract-
Palavras-chave: dc.subjecthigh-fat diet-
Palavras-chave: dc.subjectwestern diet-
Título: dc.titleGastric plication surgery changes gastrointestinal and metabolic parameters in an obesity-induced high-fat diet model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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