Transition between peritoneal dialysis modalities: Impact on blood pressure levels and drug prescription in a national multicentric cohort

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Autor(es): dc.contributorPontifícia Universidade Católica do Paraná (PUCPR)-
Autor(es): dc.contributorFresenius Medical Care-
Autor(es): dc.contributorRenal Research Institute-
Autor(es): dc.contributorIcahn School of Medicine at Mount Sinai-
Autor(es): dc.contributorArbor Research Collaborative for Health-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDariva, Marcus-
Autor(es): dc.creatorGuedes, Murilo-
Autor(es): dc.creatorRigodon, Vladimir-
Autor(es): dc.creatorKotanko, Peter-
Autor(es): dc.creatorLarkin, John W-
Autor(es): dc.creatorFerlin, Bruno-
Autor(es): dc.creatorPecoits-Filho, Roberto-
Autor(es): dc.creatorBarretti, Pasqual-
Autor(es): dc.creatorde Moraes, Thyago Proença-
Data de aceite: dc.date.accessioned2025-08-21T22:58:02Z-
Data de disponibilização: dc.date.available2025-08-21T22:58:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/08968608241240566-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306853-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306853-
Descrição: dc.descriptionBackground: Hypertension is a leading cause of kidney failure, affects most dialysis patients and associates with adverse outcomes. Hypertension can be difficult to control with dialysis modalities having differential effects on sodium and water removal. There are two main types of peritoneal dialysis (PD), automated peritoneal dialysis (APD) and continuous ambulatory peritoneal dialysis (CAPD). It is unknown whether one is superior to the other in controlling blood pressure (BP). Therefore, the aim of our study was to analyse the impact of switching between these two PD modalities on BP levels in a nationally representative cohort. Methods: This was a cohort study of patients on PD from 122 dialysis centres in Brazil (BRAZPD II study). Clinical and laboratory data were collected monthly throughout the study duration. We selected all patients who remained on PD at least 6 months and 3 months on each modality at minimum. We compared the changes in mean systolic/diastolic blood pressures (SBP/DBP) before and after modality transition using a multilevel mixed-model where patients were at first level and their clinics at the second level. Results: We analysed data of 848 patients (814 starting on CAPD and 34 starting on APD). The SBP decreased by 4 (SD 22) mmHg when transitioning from CAPD to APD (p < 0.001) and increased by 4 (SD 21) mmHg when transitioning from APD to CAPD (p = 0.38); consistent findings were seen for DBP. There was no significant change in the number of antihypertensive drugs prescribed before and after transition. Conclusions: Transition between PD modalities seems to directly impact on BP levels. Further studies are needed to confirm if switching to APD could be an effective treatment for uncontrolled hypertension among CAPD patients.-
Descrição: dc.descriptionPontifícia Universidade Católica do Paraná (PUCPR)-
Descrição: dc.descriptionGlobal Medical Office Fresenius Medical Care-
Descrição: dc.descriptionRenal Research Institute-
Descrição: dc.descriptionIcahn School of Medicine at Mount Sinai-
Descrição: dc.descriptionArbor Research Collaborative for Health, Ann Arbor-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionUniversidade Estadual Paulista (UNESP)-
Formato: dc.format44-51-
Idioma: dc.languageen-
Relação: dc.relationPeritoneal Dialysis International-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAPD-
Palavras-chave: dc.subjectCAPD-
Palavras-chave: dc.subjectchronic kidney disease-
Palavras-chave: dc.subjectmulticenter study-
Palavras-chave: dc.subjectsystemic arterial hypertension-
Título: dc.titleTransition between peritoneal dialysis modalities: Impact on blood pressure levels and drug prescription in a national multicentric cohort-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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