Telocytes: current methods of research, challenges and future perspectives

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Birmingham-
Autor(es): dc.contributorUtrecht University-
Autor(es): dc.contributorRegenerative Medicine Center Utrecht-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSanches, Bruno D. A.-
Autor(es): dc.creatorTeófilo, Francisco B. S.-
Autor(es): dc.creatorBrunet, Mathieu Y.-
Autor(es): dc.creatorVillapun, Victor M.-
Autor(es): dc.creatorMan, Kenny-
Autor(es): dc.creatorRocha, Lara C.-
Autor(es): dc.creatorNeto, Jurandyr Pimentel-
Autor(es): dc.creatorMatsumoto, Marta R.-
Autor(es): dc.creatorMaldarine, Juliana S.-
Autor(es): dc.creatorCiena, Adriano P.-
Autor(es): dc.creatorCox, Sophie C.-
Autor(es): dc.creatorCarvalho, Hernandes F.-
Data de aceite: dc.date.accessioned2025-08-21T19:20:07Z-
Data de disponibilização: dc.date.available2025-08-21T19:20:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00441-024-03888-5-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306835-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306835-
Descrição: dc.descriptionTelocytes (TCs) are CD34-positive interstitial cells that have long cytoplasmic projections, called telopodes; they have been identified in several organs and in various species. These cells establish a complex communication network between different stromal and epithelial cell types, and there is growing evidence that they play a key role in physiology and pathology. In many tissues, TC network impairment has been implicated in the onset and progression of pathological conditions, which makes the study of TCs of great interest for the development of novel therapies. In this review, we summarise the main methods involved in the characterisation of these cells as well as their inherent difficulties and then discuss the functional assays that are used to uncover the role of TCs in normal and pathological conditions, from the most traditional to the most recent. Furthermore, we provide future perspectives in the study of TCs, especially regarding the establishment of more precise markers, commercial lineages and means for drug delivery and genetic editing that directly target TCs.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biology State University of Campinas (UNICAMP), Carl von Linnaeus St. Bldg G1, Bertrand Russel Ave., São Paulo-
Descrição: dc.descriptionSchool of Chemical Engineering University of Birmingham, Edgbaston-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery & amp; Special Dental Care University Medical Center Utrecht Utrecht University-
Descrição: dc.descriptionRegenerative Medicine Center Utrecht-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), 1515 24 A Ave., São Paulo-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), 1515 24 A Ave., São Paulo-
Descrição: dc.descriptionFAPESP: 2021/02303-7-
Formato: dc.format141-155-
Idioma: dc.languageen-
Relação: dc.relationCell and Tissue Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectImmunomarkers-
Palavras-chave: dc.subjectMethods-
Palavras-chave: dc.subjectSingle-cell RNAseq-
Palavras-chave: dc.subjectTelocytes-
Palavras-chave: dc.subjectUltrastructure-
Título: dc.titleTelocytes: current methods of research, challenges and future perspectives-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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