GABAergic and glutamatergic transmission reveals novel cardiovascular and urinary bladder control features in the shell nucleus accumbens

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorCentro Universitario FMABC-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Gothenburg-
Autor(es): dc.creatorde Carvalho, Rodrigo P.-
Autor(es): dc.creatordo Vale, Bárbara-
Autor(es): dc.creatorDsouki, Nuha A.-
Autor(es): dc.creatorCafarchio, Eduardo M.-
Autor(es): dc.creatorDe Luca, Laurival A.-
Autor(es): dc.creatorAronsson, Patrik-
Autor(es): dc.creatorSato, Monica A.-
Data de aceite: dc.date.accessioned2025-08-21T17:06:03Z-
Data de disponibilização: dc.date.available2025-08-21T17:06:03Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2023.148520-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306787-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306787-
Descrição: dc.descriptionThe shell Nucleus Accumbens (NAcc) projects to the lateral preoptic area, which is involved in the central micturition control and receives inputs from medullary areas involved in cardiovascular control. We investigated the role of GABAergic and glutamatergic transmission in the shell NAcc on intravesical pressure (IP) and cardiovascular control. Male Wistar rats with guide cannulas implanted bilaterally in the shell NAcc 7 days prior to the experiments were anesthetized with 2% isoflurane in 100% O2 and subjected to cannulation of the femoral artery and vein for mean arterial pressure (MAP) and heart rate recordings (HR) and infusion of drugs, respectively. The urinary bladder (UB) was cannulated for IP measurement. A Doppler flow probe was placed around the renal arterial for renal blood flow (RBF) measurement. After the baseline MAP, HR, IP and RBF recordings for 15 min, GABA or bicuculline methiodate (BMI) or L-glutamate or kynurenic acid (KYN) or saline (vehicle) were bilaterally injected into the shell NAcc and the variables were measured for 30 min. Data are as mean ± SEM and submitted to Student́s t test. GABA injections into the shell NAcc evoked a significant fall in MAP and HR and increased IP and RC compared to saline. L-glutamate in the shell NAcc increased MAP, HR and IP and reduced RC. Injections of BMI and KYN elicited no changes in the variables recorded. Therefore, the GABAergic and glutamatergic transmissions in neurons in the shell NAcc are involved in the neural pathways responsible for the central cardiovascular control and UB regulation.-
Descrição: dc.descriptionDept. Morphology and Physiology Faculdade de Medicina do ABC Centro Universitario FMABC, SP-
Descrição: dc.descriptionDept. Physiology and Pathology School of Dentistry São Paulo State University – UNESP, SP-
Descrição: dc.descriptionDept Pharmacology Institute of Neuroscience and Physiology Sahlgrenska Academy University of Gothenburg-
Descrição: dc.descriptionDept. Physiology and Pathology School of Dentistry São Paulo State University – UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationBrain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArterial pressure-
Palavras-chave: dc.subjectHeart rate-
Palavras-chave: dc.subjectIntravesical pressure-
Palavras-chave: dc.subjectRenal blood flow-
Palavras-chave: dc.subjectShell nucleus accumbens-
Título: dc.titleGABAergic and glutamatergic transmission reveals novel cardiovascular and urinary bladder control features in the shell nucleus accumbens-
Tipo de arquivo: dc.typelivro digital-
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