SARS-CoV-2 Lineage P.4 Detection in Southeast Brazil: A Retrospective Genomic and Clinical Overview

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorMunicipal Epidemiological Surveillance-
Autor(es): dc.contributorFundação Oswaldo Cruz-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorNGS Soluções Genômicas-
Autor(es): dc.contributorMendelics Genomic Analysis-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSão José do Rio-
Autor(es): dc.creatorPoleti, Mirele Daiana-
Autor(es): dc.creatorLesbon, Jéssika Cristina Chagas-
Autor(es): dc.creatorde Mattos Oliveira, Elisângela Chicaroni-
Autor(es): dc.creatorPatané, José Salvatore Leister-
Autor(es): dc.creatorClemente, Luan Gaspar-
Autor(es): dc.creatorViala, Vincent Louis-
Autor(es): dc.creatorRibeiro, Gabriela-
Autor(es): dc.creatorPinheiro, Jéssica Fernanda Perissato-
Autor(es): dc.creatorGiovanetti, Marta-
Autor(es): dc.creatorAlcantara, Luiz Carlos Junior-
Autor(es): dc.creatorde Lima, Loyze Paola Oliveira-
Autor(es): dc.creatorMartins, Antonio Jorge-
Autor(es): dc.creatordos Santos Barros, Claudia Renata-
Autor(es): dc.creatorMarqueze, Elaine Cristina-
Autor(es): dc.creatorde Souza Todão Bernardino, Jardelina-
Autor(es): dc.creatorMoretti, Debora Botequio-
Autor(es): dc.creatorBrassaloti, Ricardo Augusto-
Autor(es): dc.creatorde Lello Rocha Campos Cassano, Raquel-
Autor(es): dc.creatorMariani, Pilar Drummond Sampaio Corrêa-
Autor(es): dc.creatorSlavov, Svetoslav Nanev-
Autor(es): dc.creatordos Santos Bezerra, Rafael-
Autor(es): dc.creatorRodrigues, Evandra Strazza-
Autor(es): dc.creatorSantos, Elaine Vieira-
Autor(es): dc.creatorBorges, Josiane Serrano-
Autor(es): dc.creatorde La Roque, Debora Glenda Lima-
Autor(es): dc.creatorKitajima, João Paulo-
Autor(es): dc.creatorSantos, Bibiana-
Autor(es): dc.creatorAssato, Patrícia Akemi-
Autor(es): dc.creatorda Silva da Costa, Felipe Allan-
Autor(es): dc.creatorBanho, Cecília Ártico-
Autor(es): dc.creatorSacchetto, Lívia-
Autor(es): dc.creatorde Carvalho Marques, Beatriz-
Autor(es): dc.creatorGrotto, Rejane Maria Tommasini-
Autor(es): dc.creatorSouza-Neto, Jayme A.-
Autor(es): dc.creatorNogueira, Maurício Lacerda-
Autor(es): dc.creatorCoutinho, Luiz Lehmann-
Autor(es): dc.creatorCalado, Rodrigo Tocantins-
Autor(es): dc.creatorNeto, Raul Machado-
Autor(es): dc.creatorCovas, Dimas Tadeu-
Autor(es): dc.creatorKashima, Simone-
Autor(es): dc.creatorElias, Maria Carolina-
Autor(es): dc.creatorSampaio, Sandra Coccuzzo-
Autor(es): dc.creatorFukumasu, Heidge-
Data de aceite: dc.date.accessioned2025-08-21T17:34:51Z-
Data de disponibilização: dc.date.available2025-08-21T17:34:51Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/covid2120127-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306738-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306738-
Descrição: dc.descriptionSão Paulo state has been the epicenter of the Coronavirus Disease 2019 (COVID-19) in Brazil, ranking first by state with over six million reported cases. In February 2021, the P.4 lineage was reported in 21 cities across the state by public health authorities due to the L452R mutation. Here, by analyzing 17,304 genome sequences of SARS-CoV-2 sampled between February and August of 2021 in 476 distinct cities in São Paulo, we assess the transmission dynamics of the P.4 lineage and other SARS-CoV-2 variants that were, at the time of the study, co-circulating in the state. Additionally, clinical parameters from the city of Araras, São Paulo (N = 251) were considered to estimate the potential risk and mortality rate associated with the P.4 lineage since its higher prevalence was observed in that city. Our data suggest a low frequency (0.55%) of the P.4 lineage across the state, with the gamma variant being the dominant form in all regions (90%) at that time. Furthermore, no evidence of increased transmissibility and disease severity related to the P.4 lineage was observed. The displacement through the time of different lineages in São Paulo highlights how challenging genomic surveillance appears to track the emergence of new SARS-CoV-2 lineages, which could better guide the implementation of control measures.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Comparative and Translational Oncology Department of Veterinary Medicine School of Animal Science and Food Engineering University of Sao Paulo, SP-
Descrição: dc.descriptionButantan Institute, SP-
Descrição: dc.descriptionFunctional Genomic Center Department of Animal Science Luiz de Queiroz School of Agriculture University of Sao Paulo, SP-
Descrição: dc.descriptionMunicipal Epidemiological Surveillance, SP-
Descrição: dc.descriptionFundação Oswaldo Cruz, RJ-
Descrição: dc.descriptionInstitute of Biological Sciences Federal University of Minas Gerais, MG-
Descrição: dc.descriptionNGS Soluções Genômicas, SP-
Descrição: dc.descriptionBlood Center of Ribeirao Preto Ribeirao Preto Medical School University of Sao Paulo-
Descrição: dc.descriptionMendelics Genomic Analysis, SP-
Descrição: dc.descriptionSchool of Agricultural Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionLaboratório de Pesquisas em Virologia Medicine School of São José do Rio Preto São José do Rio, SP-
Descrição: dc.descriptionSchool of Agricultural Sciences Sao Paulo State University, SP-
Descrição: dc.descriptionFAPESP: 2020/06136-5-
Formato: dc.format1768-1777-
Idioma: dc.languageen-
Relação: dc.relationCOVID-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectgenomic surveillance-
Palavras-chave: dc.subjectmutations-
Palavras-chave: dc.subjectSão Paulo-
Título: dc.titleSARS-CoV-2 Lineage P.4 Detection in Southeast Brazil: A Retrospective Genomic and Clinical Overview-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.