Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorLabEx IGO-
Autor(es): dc.contributorPole Biologie-Centre Hospitalier Universitaire (CHU) Rennes-
Autor(es): dc.contributorUMR 1064-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCIC 1413-
Autor(es): dc.contributorUniversity Claude Bernard Lyon 1-
Autor(es): dc.contributorPathologies de la Myéline et Neuro-Inflammation-
Autor(es): dc.contributorUMR 5292-
Autor(es): dc.contributorState-Approved Foundation-
Autor(es): dc.contributorLille University Hospital-
Autor(es): dc.contributorRennes University Hospital-Rennes University-Institut National de la Santé et de la Recherche Médicale (INSERM)-
Autor(es): dc.contributorNimes University Hospital-
Autor(es): dc.contributorUniversité de Montpellier-
Autor(es): dc.contributorInstitut National de la Santé et de la Recherche Médicale (INSERM) U1215-
Autor(es): dc.contributorCHU de Bordeaux-
Autor(es): dc.contributorNancy University Hospital-
Autor(es): dc.contributorINSPIIRE-
Autor(es): dc.creatorRodriguez, Stéphane-
Autor(es): dc.creatorCouloume, Laura-
Autor(es): dc.creatorFerrant, Juliette-
Autor(es): dc.creatorVince, Nicolas-
Autor(es): dc.creatorMandon, Marion-
Autor(es): dc.creatorJean, Rachel-
Autor(es): dc.creatorMonvoisin, Celine-
Autor(es): dc.creatorLeonard, Simon-
Autor(es): dc.creatorLe Gallou, Simon-
Autor(es): dc.creatorSilva, Nayane S. B.-
Autor(es): dc.creatorBourguiba-Hachemi, Sonia-
Autor(es): dc.creatorLaplaud, David-
Autor(es): dc.creatorGarcia, Alexandra-
Autor(es): dc.creatorCasey, Romain-
Autor(es): dc.creatorZephir, Helene-
Autor(es): dc.creatorKerbrat, Anne-
Autor(es): dc.creatorEdan, Gilles-
Autor(es): dc.creatorLepage, Emmanuelle-
Autor(es): dc.creatorThouvenot, Eric-
Autor(es): dc.creatorRuet, Aurelie-
Autor(es): dc.creatorMathey, Guillaume-
Autor(es): dc.creatorGourraud, Pierre-Antoine-
Autor(es): dc.creatorTarte, Karin-
Autor(es): dc.creatorDelaloy, Celine-
Autor(es): dc.creatorAmé, Patricia-
Autor(es): dc.creatorRoussel, Mikael-
Autor(es): dc.creatorMichel, Laure-
Data de aceite: dc.date.accessioned2025-08-21T21:01:56Z-
Data de disponibilização: dc.date.available2025-08-21T21:01:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fimmu.2024.1494842-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306726-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306726-
Descrição: dc.descriptionIntroduction: Myeloid cells trafficking from the periphery to the central nervous system are key players in multiple sclerosis (MS) through antigen presentation, cytokine secretion and repair processes. Methods: Combination of mass cytometry on blood cells from 60 MS patients at diagnosis and 29 healthy controls, along with single cell RNA sequencing on paired blood and cerebrospinal fluid (CSF) samples from 5 MS patients were used for myeloid cells detailing. Results: Myeloid compartment study demonstrated an enrichment of a peculiar classical monocyte population in 22% of MS patients at the time of diagnosis. Notably, this patients’ subgroup exhibited a more aggressive disease phenotype two years post-diagnosis. This monocytic population, detected in both the CSF and blood, was characterized by CD206, CD209, CCR5 and CCR2 expression, and was found to be more frequent in MS patients carrying the HLA-DRB1*15:01 allele. Furthermore, pathways analysis predicted that these cells had antigen presentation capabilities coupled with pro-inflammatory phenotype. Discussion: Altogether, these results point toward the amplification of a specific and pathogenic myeloid cell subset in MS patients with genetic susceptibilities.-
Descrição: dc.descriptionFondation pour l'Aide à la Recherche sur la Sclérose en Plaques-
Descrição: dc.descriptionInstitut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche U1236 Université Rennes Etablissement Français du Sang Bretagne LabEx IGO-
Descrição: dc.descriptionPole Biologie-Centre Hospitalier Universitaire (CHU) Rennes-
Descrição: dc.descriptionInstitut National de la Santé et de la Recherche Médicale (INSERM) Centre Hospitalier Universitaire (CHU) Nantes Nantes University Center for Research in Transplantation and Translational Immunology UMR 1064-
Descrição: dc.descriptionSão Paulo State University Molecular Genetics and Bioinformatics Laboratory School of Medicine-
Descrição: dc.descriptionService de Neurologie Centre Hospitalier Universitaire (CHU) Nantes CRC-SEP Pays de la Loire CIC 1413-
Descrição: dc.descriptionLyon University University Claude Bernard Lyon 1-
Descrição: dc.descriptionHospices Civils de Lyon Neurology Department Sclérose en Plaques Pathologies de la Myéline et Neuro-Inflammation-
Descrição: dc.descriptionObservatoire Français de la Sclérose en Plaques Centre de Recherche en Neurosciences de Lyon INSERM 1028 CNRS UMR 5292-
Descrição: dc.descriptionEUGENE DEVIC EDMUS Foundation against Multiple Sclerosis State-Approved Foundation-
Descrição: dc.descriptionLille University Inserm U1172 Lille University Hospital-
Descrição: dc.descriptionNeurology Department Rennes Clinical Investigation Centre Rennes University Hospital-Rennes University-Institut National de la Santé et de la Recherche Médicale (INSERM)-
Descrição: dc.descriptionDepartment of Neurology Nimes University Hospital-
Descrição: dc.descriptionInstitut de Génomique Fonctionnelle UMR5203 Inserm 1191 Université de Montpellier-
Descrição: dc.descriptionNeurocentre Magendie Institut National de la Santé et de la Recherche Médicale (INSERM) U1215-
Descrição: dc.descriptionCHU de Bordeaux Department of Neurology-
Descrição: dc.descriptionDepartment of Neurology Nancy University Hospital-
Descrição: dc.descriptionUniversité de Lorraine Inserm INSPIIRE-
Descrição: dc.descriptionSão Paulo State University Molecular Genetics and Bioinformatics Laboratory School of Medicine-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantigen presentation-
Palavras-chave: dc.subjectcerebrospinal fluid-
Palavras-chave: dc.subjectclassical monocyte-
Palavras-chave: dc.subjectdisability-
Palavras-chave: dc.subjectmultiple sclerosis-
Título: dc.titleBlood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution-
Tipo de arquivo: dc.typelivro digital-
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