Analysis of dentin wear and biological properties promoted by experimental inoffice desensitizing materials

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Toronto-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorSilva Ramos, Fernanda de Souza-
Autor(es): dc.creatorde Castro Oliveira, Laryssa-
Autor(es): dc.creatorAlbertinazzi, Larissa-
Autor(es): dc.creatorBezerra, Sávio José Cardoso-
Autor(es): dc.creatordos Santos, Vanessa Rodrigues-
Autor(es): dc.creatorScaramucci, Tais-
Autor(es): dc.creatorDuque, Cristiane-
Autor(es): dc.creatorGanss, Bernhard-
Autor(es): dc.creatorSouza, Marina Trevelin-
Autor(es): dc.creatorPessan, Juliano Pelim-
Autor(es): dc.creatorFagundes, Ticiane Cestari-
Data de aceite: dc.date.accessioned2025-08-21T21:30:08Z-
Data de disponibilização: dc.date.available2025-08-21T21:30:08Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s12903-024-04373-9-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306669-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306669-
Descrição: dc.descriptionBackground: This study aimed to evaluate dentin wear and biological performance of desensitizing materials. Methods: Seventy bovine root dentin blocks were sectioned. Half of the surface of each specimen was untreated (control) and the other half was immersed in EDTA and treated with the following desensitizing materials: placebo varnish (PLA), fluoride varnish (FLU), sodium fluoride (NaF) varnish + sodium trimetaphosphate (TMP), universal adhesive (SBU), S-PRG varnish (SPRG), biosilicate (BIOS), and amelotin solution (AMTN). After application, the specimens were submitted to an erosive-abrasive challenge and the wear analyzed by optical profilometer. Serial dilutions of extracts obtained from the culture medium containing discs impregnated with those desensitizers were applied on fibroblasts and odontoblasts-like cells cultures. Cytotoxicity and production of total protein (TP) by colorimetric assays were determined after 24 h. Data were statistically analyzed using Kruskal-Wallis, Dunn’s, One-way ANOVA and Tukey tests (p ≤ 0.05). Results: No dentin wear was observed only for SBU. The lowest dentin wear was observed for AMTN and TMP. Cell viability was significantly reduced after treatment with undiluted extracts of PLA, FLU, TMP and SBU in fibroblasts and TMP and SBU in odontoblast-like cells. SPRG, BIOS and AMTN were cytocompatible at all dilutions tested. Considering TP results, no statistical difference was observed among the groups and high levels for TP were observed after TMP and FLU treatments. Conclusions: Universal adhesive system may protect dentin with opened tubules from wear after challenge. Extracts of adhesive and fluoride varnishes presented cytotoxic mainly on fibroblasts. The enamel protein may be a future alternative to treat dentin with opened tubules because it may cause low wear under erosive-abrasive challenge with low cytotoxic effects.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Restorative Dentistry University of São Paulo (USP) School of Dentistry, SP-
Descrição: dc.descriptionFaculty of Dentistry Institute of Biomedical Engineering University of Toronto-
Descrição: dc.descriptionVitreous Materials Laboratory Department of Materials Engineering Federal University of São Carlos, SP-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionFAPESP: 2020/07443-9-
Descrição: dc.descriptionFAPESP: 2020/07625-0-
Descrição: dc.descriptionCAPES: 5716/2022-4-
Idioma: dc.languageen-
Relação: dc.relationBMC Oral Health-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell biology-
Palavras-chave: dc.subjectCytotoxicity tests-
Palavras-chave: dc.subjectDental abrasion-
Palavras-chave: dc.subjectDental erosion-
Palavras-chave: dc.subjectDentin sensitivity-
Palavras-chave: dc.subjectDesensitizing agents-
Título: dc.titleAnalysis of dentin wear and biological properties promoted by experimental inoffice desensitizing materials-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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