Is micronucleus assay a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage induced by chemical, physical, and biological agents in vivo? A systematic review with meta-analysis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.creatorPinto, Thiago Guedes-
Autor(es): dc.creatorTakeshita, Wilton Mitsunari-
Autor(es): dc.creatorRenno, Ana Claudia Muniz-
Autor(es): dc.creatorCury, Patricia Ramos-
Autor(es): dc.creatordos Santos, Jean Junes-
Autor(es): dc.creatorRibeiro, Daniel Araki-
Data de aceite: dc.date.accessioned2025-08-21T20:24:43Z-
Data de disponibilização: dc.date.available2025-08-21T20:24:43Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jat.4662-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306608-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306608-
Descrição: dc.descriptionThe present systematic review (SR) aims to evaluate manuscripts in order to help further elucidate the following question: is the micronucleus assay (MA) also a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage in vivo? A search was performed through the electronic databases PubMed/Medline, Scopus, and Web of Science, all studies published up to December 2023. The comparisons were defined as standardized mean difference (SMD), and 95% confidence intervals (CIs) were established. Full manuscripts from 34 studies were carefully selected and reviewed in this setting. Our results demonstrate that the MA may be a useful biomarker of gingival tissue damage in vivo, and this tissue could be a useful alternative to the buccal mucosa. The meta-analysis analyzing the different sites regardless of the deleterious factor studied, the buccal mucosa (SMD = 0.69, 95% CI, − 0.49 to 1.88, p = 0.25) and gingiva (SMD = 0.31, 95% CI, − 0.11 to 0.72, p = 0.15), showed similar results and different outcome for the tongue (SMD = 1.19, 95% CI, 0.47 to 1.91, p = 0.001). In summary, our conclusion suggests that the MA can be a useful marker for detecting DNA damage in gingiva in vivo and that this tissue could be effective site for smearing.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Biosciences Institute of Health and Society Federal University of São Paulo UNIFESP, SP-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDentistry and Health Postgraduate Program School of Dentistry Federal University of Bahia-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery São Paulo State University (UNESP) School of Dentistry, SP-
Formato: dc.format117-134-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectgenotoxicity-
Palavras-chave: dc.subjectgingiva-
Palavras-chave: dc.subjectmicronucleus assay-
Palavras-chave: dc.subjectoral mucosa-
Palavras-chave: dc.subjectpalate-
Palavras-chave: dc.subjectrisk assessment-
Palavras-chave: dc.subjecttongue-
Título: dc.titleIs micronucleus assay a useful marker in gingiva, tongue, and palate for evaluating cytogenetic damage induced by chemical, physical, and biological agents in vivo? A systematic review with meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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