Increased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of ABC-
Autor(es): dc.contributorand Teaching in Neuromodulation)-
Autor(es): dc.contributorBahia Adventist College-
Autor(es): dc.contributorUniversity of Balearic Islands-
Autor(es): dc.contributorEscola Bahiana de Medicina e Saúde Pública-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLopes, Tiago S.-
Autor(es): dc.creatorSantana, Jamille E.-
Autor(es): dc.creatorSilva, Wellington S.-
Autor(es): dc.creatorFraga, Francisco J.-
Autor(es): dc.creatorMontoya, Pedro-
Autor(es): dc.creatorSá, Katia N.-
Autor(es): dc.creatorLopes, Larissa C.-
Autor(es): dc.creatorLucena, Rita-
Autor(es): dc.creatorZana, Yossi-
Autor(es): dc.creatorBaptista, Abrahão F.-
Data de aceite: dc.date.accessioned2025-08-21T22:13:20Z-
Data de disponibilização: dc.date.available2025-08-21T22:13:20Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10548-023-01027-x-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306578-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306578-
Descrição: dc.descriptionPurpose: Identify the presence of a dysfunctional electroencephalographic (EEG) pattern in individuals with sickle cell disease (SCD) and hip osteonecrosis, and assess its potential associations with depression, anxiety, pain severity, and serum levels of brain-derived neurotrophic factor (BDNF). Methods: In this cross-sectional investigation, 24 SCD patients with hip osteonecrosis and chronic pain were matched by age and sex with 19 healthy controls. Resting-state EEG data were recorded using 32 electrodes for both groups. Power spectral density (PSD) and peak alpha frequency (PAF) were computed for each electrode across Delta, Theta, Alpha, and Beta frequency bands. Current Source Density (CSD) measures were performed utilizing the built-in Statistical nonparametric Mapping Method of the LORETA-KEY software. Results: Our findings demonstrated that SCD individuals exhibited higher PSD in delta and theta frequency bands when compared to healthy controls. Moreover, SCD individuals displayed increased CSD in delta and theta frequencies, coupled with decreased CSD in the alpha frequency within brain regions linked to pain processing, motor function, emotion, and attention. In comparison to the control group, depression symptoms, and pain intensity during hip abduction were positively correlated with PSD and CSD in the delta frequency within the parietal region. Depression symptoms also exhibited a positive association with PSD and CSD in the theta frequency within the same region, while serum BDNF levels showed a negative correlation with CSD in the alpha frequency within the left insula. Conclusion: This study indicates that individuals with SCD experiencing hip osteonecrosis and chronic pain manifest a dysfunctional EEG pattern characterized by the persistence of low-frequency PSD during a resting state. This dysfunctional EEG pattern may be linked to clinical and biochemical outcomes, including depression symptoms, pain severity during movement, and serum BDNF levels.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado da Bahia-
Descrição: dc.descriptionMinisterio de Ciencia e Innovación-
Descrição: dc.descriptionCenter for Mathematics Computation and Cognition Federal University of ABC-
Descrição: dc.descriptionNAPEN network (Nucleus of Assistance Research and Teaching in Neuromodulation)-
Descrição: dc.descriptionBahia Adventist College-
Descrição: dc.descriptionEngineering Modelling and Applied Social Sciences Center Federal University of ABC, SP-
Descrição: dc.descriptionResearch Institute of Health Sciences University of Balearic Islands-
Descrição: dc.descriptionPostgraduate and Research Escola Bahiana de Medicina e Saúde Pública, Bahia-
Descrição: dc.descriptionGraduate Program in Medicine and Health Federal University of Bahia-
Descrição: dc.descriptionLaboratory of Medical Investigations 54 Clinics Hospital São Paulo State University-
Descrição: dc.descriptionLaboratory of Medical Investigations 54 Clinics Hospital São Paulo State University-
Formato: dc.format859-873-
Idioma: dc.languageen-
Relação: dc.relationBrain Topography-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBrain Rhythms-
Palavras-chave: dc.subjectEEG-
Palavras-chave: dc.subjectJoint Chronic Pain-
Palavras-chave: dc.subjectNeuroscience-
Palavras-chave: dc.subjectSickle cell Disease-
Título: dc.titleIncreased Delta and Theta Power Density in Sickle Cell Disease Individuals with Chronic Pain Secondary to Hip Osteonecrosis: A Resting-State Eeg Study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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