Obesity-dependent molecular alterations in fatal COVID-19: A retrospective postmortem study of metabolomic profile of adipose tissue

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Autor(es): dc.contributorPontifícia Universidade Católica do Paraná-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorBrazilian Center for Research in Energy and Materials-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPilger, Bruna I.-
Autor(es): dc.creatorCastro, Alex-
Autor(es): dc.creatorVasconcellos, Franciane F.-
Autor(es): dc.creatorMoura, Karen F.-
Autor(es): dc.creatorSignini, Étore De Favari-
Autor(es): dc.creatorMarqueze, Luis Felipe B.-
Autor(es): dc.creatorFiorenza-Neto, Edson A.-
Autor(es): dc.creatorRocha, Mateus T.-
Autor(es): dc.creatorPedroso, Giulia S.-
Autor(es): dc.creatorCavaglieri, Claudia R.-
Autor(es): dc.creatorFerreira, Antonio G.-
Autor(es): dc.creatorFigueiredo, Caique-
Autor(es): dc.creatorMinuzzi, Luciele G.-
Autor(es): dc.creatorGatti da Silva, Guilherme H.-
Autor(es): dc.creatorCastro, Gabriela S.-
Autor(es): dc.creatorLira, Fábio S.-
Autor(es): dc.creatorSeelaender, Marilia-
Autor(es): dc.creatorPinho, Ricardo A.-
Data de aceite: dc.date.accessioned2025-08-21T20:57:24Z-
Data de disponibilização: dc.date.available2025-08-21T20:57:24Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jcb.30566-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306560-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306560-
Descrição: dc.descriptionWe investigated the effects of obesity on metabolic, inflammatory, and oxidative stress parameters in the adipose tissue of patients with fatal COVID-19. Postmortem biopsies of subcutaneous adipose tissue were obtained from 25 unvaccinated inpatients who passed from COVID-19, stratified as nonobese (N-OB; body mass index [BMI], 26.5 ± 2.3 kg m−2) or obese (OB BMI 34.2 ± 5.1 kg m−2). Univariate and multivariate analyses revealed that body composition was responsible for most of the variations detected in the metabolome, with greater dispersion observed in the OB group. Fifteen metabolites were major segregation factors. Results from the OB group showed higher levels of creatinine, myo-inositol, O-acetylcholine, and succinate, and lower levels of sarcosine. The N-OB group showed lower levels of glutathione peroxidase activity, as well as higher content of IL-6 and adiponectin. We revealed significant changes in the metabolomic profile of the adipose tissue in fatal COVID-19 cases, with high adiposity playing a key role in these observed variations. These findings highlight the potential involvement of metabolic and inflammatory pathways, possibly dependent on hypoxia, shedding light on the impact of obesity on disease pathogenesis and suggesting avenues for further research and possible therapeutic targets.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionGraduate Program in Health Sciences School of Medicine and Life Sciences Pontifícia Universidade Católica do Paraná-
Descrição: dc.descriptionLaboratory of Nuclear Magnetic Resonance Department of Chemistry Universidade Federal de São Carlos-
Descrição: dc.descriptionBiosciences National Laboratory Brazilian Center for Research in Energy and Materials-
Descrição: dc.descriptionCardiovascular Physical Therapy Laboratory Department of Physical Therapy Universidade Federal de São Carlos-
Descrição: dc.descriptionExercise Physiology Laboratory Faculty of Physical Education University of Campinas-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista-
Descrição: dc.descriptionCancer Metabolism Research Group Department of Surgery and LIM 26 Hospital das Clínicas University of São Paulo-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Post-Graduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista-
Descrição: dc.descriptionFAPESP: 2020/13939–7-
Descrição: dc.descriptionCNPq: 307669/2019-0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Cellular Biochemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjecthypoxia-
Palavras-chave: dc.subjectinflammation-
Palavras-chave: dc.subjectmetabolome-
Palavras-chave: dc.subjectobesity-
Palavras-chave: dc.subjectoxidative stress-
Título: dc.titleObesity-dependent molecular alterations in fatal COVID-19: A retrospective postmortem study of metabolomic profile of adipose tissue-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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