Incidence of Bacteriobilia and the Correlation with Antibioticoprophylaxis in Low-Risk Patients Submitted to Elective Videolaparoscopic Cholecystectomy: A Randomized Clinical Trial

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Autor(es): dc.contributorUniversity of Marilia (UNIMAR)-
Autor(es): dc.contributorUniversity of West Paulista (UNOESTE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEducational Foundation of the Municipality of Assis (FEMA)-
Autor(es): dc.contributorUniversity Center of Adamantina (UNIFAI)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorPagani, Marcos Alberto-
Autor(es): dc.creatorDolfini, Pedro Meira-
Autor(es): dc.creatorTrazzi, Beatriz Flávia de Moraes-
Autor(es): dc.creatorDolfini, Maria Ines Meira-
Autor(es): dc.creatorda Silva, William Saranholi-
Autor(es): dc.creatorChagas, Eduardo Federighi Baisi-
Autor(es): dc.creatorReis, Carlos Henrique Bertoni-
Autor(es): dc.creatorPilon, João Paulo Galletti-
Autor(es): dc.creatorPagani, Bruna Trazzi-
Autor(es): dc.creatorStrasser, Rodrigo Tavore-
Autor(es): dc.creatorMendes, Claudemir Gregório-
Autor(es): dc.creatorVernaschi, Fausto Tucunduva-
Autor(es): dc.creatorBuchaim, Daniela Vieira-
Autor(es): dc.creatorBuchaim, Rogerio Leone-
Data de aceite: dc.date.accessioned2025-08-21T16:15:10Z-
Data de disponibilização: dc.date.available2025-08-21T16:15:10Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics12101480-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306468-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306468-
Descrição: dc.descriptionCholelithiasis has a major impact on global health and affects an average of 20% of the Western population. The main risk factors are females, age over 40 years, obesity and pregnancy. Most of the time it is asymptomatic, but when there are symptoms, they are generally nonspecific. Bile was considered sterile, but today it is known that it contains a complex bacterial flora, which causes biofilm in the gallbladder and gallstones. Among the main bacteria associated with cholelithiasis are Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, species of Enterococcus spp. and Acinetobacter spp. Antibiotic prophylaxis is used in an attempt to reduce postoperative infections, especially at the surgical site. However, some authors found no relationship between the use of antibiotic prophylaxis and a lower risk of surgical site infection. Thus, the aim of this double-blind randomized clinical trial was to compare the existence or not of bacteriobilia in patients at low anesthetic risk who underwent videolaparoscopic cholecystectomy, and its correlation with the use of prophylactic antibiotics. This study included 40 patients between 18 and 65 years old, diagnosed with cholelithiasis, symptomatic or not, with low anesthetic risk classified by the American Society of Anesthesiology in ASA I or ASA II, without complications or previous manipulation of the bile duct, who underwent elective video cholecystectomy, divided into two groups: Experimental Group A (n = 20), which received 2 g of Cephalotin (first-generation Cephalosporin, Keflin®, ABL antibiotics, Cosmópolis, Brazil) during anesthetic induction, and Control Group B (n = 20), where no antibiotics were administered until bile collection. After the procedure, a bile sample was collected and culture and antibiogram were performed. In the sample, 22 (55%) were classified as ASA I and 18 (45%) as ASA II. It was observed that 81.8% of the patients who had a positive culture did not use antibiotics, against 18.2% of those who used prophylaxis. When comparing patients regarding anesthetic risk, ASA I patients had a positive culture in 9.1% of cases, against 90.9% in patients classified as ASA II. It was concluded that patients with higher anesthetic risk (ASA II) have a higher chance of bacteriobilia and benefit from antibiotic prophylaxis when compared to patients with lower anesthetic risk (ASA I).-
Descrição: dc.descriptionUNIMAR Beneficent Hospital (HBU) Medical School University of Marilia (UNIMAR)-
Descrição: dc.descriptionDepartment of General Surgery Regional Hospital University of West Paulista (UNOESTE)-
Descrição: dc.descriptionDentistry School University of Marilia (UNIMAR)-
Descrição: dc.descriptionMorphofunctional Department University of West Paulista (UNOESTE)-
Descrição: dc.descriptionPostgraduate Program in Structural and Functional Interactions in Rehabilitation University of Marilia (UNIMAR)-
Descrição: dc.descriptionInterdisciplinary Center on Diabetes (CENID) University of Marilia (UNIMAR)-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Universidade Estadual Paulista)-
Descrição: dc.descriptionFaculty of Pharmacy and Biomedicine University of Marilia (UNIMAR)-
Descrição: dc.descriptionMedical School Educational Foundation of the Municipality of Assis (FEMA)-
Descrição: dc.descriptionMedical School University Center of Adamantina (UNIFAI)-
Descrição: dc.descriptionGraduate Program in Anatomy of Domestic and Wild Animals Faculty of Veterinary Medicine and Animal Science University of Sao Paulo-
Descrição: dc.descriptionDepartment of Biological Sciences Bauru School of Dentistry (FOB/USP) University of Sao Paulo-
Descrição: dc.descriptionPostgraduate Program in Speech Therapy Sao Paulo State University (UNESP—Universidade Estadual Paulista)-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantibiotic prophylaxis-
Palavras-chave: dc.subjectbile-
Palavras-chave: dc.subjectcholecystectomy-
Palavras-chave: dc.subjectcholelithiasis-
Palavras-chave: dc.subjectrandomized clinical trial-
Palavras-chave: dc.subjectvideo-assisted surgery-
Título: dc.titleIncidence of Bacteriobilia and the Correlation with Antibioticoprophylaxis in Low-Risk Patients Submitted to Elective Videolaparoscopic Cholecystectomy: A Randomized Clinical Trial-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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