MicroRNA expression profiling in the adult offspring of rats with periodontal disease

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMattera, Maria Sara de Lima Coutinho-
Autor(es): dc.creatorScaramele, Natália Francisco-
Autor(es): dc.creatorLopes, Flávia Lombardi-
Autor(es): dc.creatorBelardi, Bianca Elvira-
Autor(es): dc.creatorTsosura, Thaís Verônica Saori-
Autor(es): dc.creatorSampaio, Heloisa Macedo-
Autor(es): dc.creatorChiba, Fernando Yamamoto-
Autor(es): dc.creatorPereira, Renato Felipe-
Autor(es): dc.creatordos Santos, Rodrigo Martins-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorBaliero, Gabriele Fernandes-
Autor(es): dc.creatorNobumoto, Ana Carla Thalez Ywabuchi-
Autor(es): dc.creatorCachoni, Anna Clara-
Autor(es): dc.creatorChaves-Neto, Antonio Hernandes-
Autor(es): dc.creatorMatsushita, Doris Hissako-
Data de aceite: dc.date.accessioned2025-08-21T17:30:42Z-
Data de disponibilização: dc.date.available2025-08-21T17:30:42Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2024.106131-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306428-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306428-
Descrição: dc.descriptionObjective: The present study investigated the relationship between maternal periodontal disease, insulin resistance, activation of inflammatory pathways and epigenetic modifications in adult offspring. Design: Therefore, female Wistar rats were divided into control and experimental groups. Seven days after the induction of periodontal disease, female rats from both groups were mated with healthy male rats. After weaning, male offspring were divided into control offspring (CN-o) and periodontal disease offspring (PED-o) groups. Body weight was measured at 0–75 days of age. At day 75, the following were measured in the offspring: insulin resistance by the HOMA-IR index; global miRNAs by microtranscriptome array; validation of the selected miRNAs by quantitative real-time PCR expression; interleukin 1 receptor associated kinase 1 (IRAK1) and tumor necrosis factor receptor-associated factor 6 (TRAF6) content in the gastrocnemius muscle tissue (GSM) by western blotting. Results: Maternal periodontal disease leads to low birth weight (LBW) in the offspring and insulin resistance in adulthood; changes in global miRNA expression (5 miRNAs upregulated and 6 downregulated); and increased protein expression of IRAK1 and TRAF6 in GSM. Conclusions: These findings demonstrate that maternal periodontal disease causes LBW, insulin resistance, activation of inflammatory pathways, and changes in global miRNA expression.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionPrograma de Pós-graduação Multicêntrico em Ciências Fisiológicas PPGMCF SBFis São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionDepartment of Preventive and Restorative Dentistry São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionDepartment of Basic Sciences São Paulo State University (UNESP) School of Dentistry, SP-
Descrição: dc.descriptionFAPESP: #2019/04183–9-
Descrição: dc.descriptionFAPESP: #2022/08872–6-
Descrição: dc.descriptionFAPESP: #2023/01400–4-
Descrição: dc.descriptionFAPESP: #2023/03786–7-
Descrição: dc.descriptionFAPESP: #2023/12488–0-
Descrição: dc.descriptionCNPq: 151151/2023–7-
Idioma: dc.languageen-
Relação: dc.relationArchives of Oral Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectInsulin resistance-
Palavras-chave: dc.subjectLow birth weight-
Palavras-chave: dc.subjectmicroRNA-
Palavras-chave: dc.subjectPeriodontal disease-
Título: dc.titleMicroRNA expression profiling in the adult offspring of rats with periodontal disease-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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