MMP-9 expression in rat pup incisor teeth is not altered by maternal hypertension or maternal atenolol treatment during pregnancy and lactation

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Autor(es): dc.contributorUniversidade Federal de Juiz de Fora- UFJF-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorElias, Gracieli Prado-
Autor(es): dc.creatorHorta, Haylla de Faria-
Autor(es): dc.creatorMateus, Alanna Ramalho-
Autor(es): dc.creatorPes, Laura Valentina Borges-
Autor(es): dc.creatorLopes, Adrielle Ouchi-
Autor(es): dc.creatorChiba, Fernando-
Autor(es): dc.creatorDelbem, Alberto Carlos Botazzo-
Autor(es): dc.creatorSassaki, Kikue Takebayashi-
Autor(es): dc.creatorOkamoto, Roberta-
Autor(es): dc.creatorAntoniali, Cristina-
Data de aceite: dc.date.accessioned2025-08-21T20:27:58Z-
Data de disponibilização: dc.date.available2025-08-21T20:27:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10735-024-10294-2-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306427-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306427-
Descrição: dc.descriptionHypertension alters tooth formation and Atenolol reduces the blood pressure of spontaneously hypertensive rats (SHR) during pregnancy and lactation, and as demonstrated before, increases the microhardness of the SHR offspring’s teeth. MMP-9 is overexpressed in different tissues of hypertensive animals and treatment of hypertension substances can reverse this alteration. We hypothesize hypertension alters the expression of MMP-9 in dental structures of SHR offspring and that treating female SHR with atenolol prevents this alteration. This study aimed to evaluate the expression of matrix metalloproteinase (MMP-9) in incisor teeth (IT) in male offspring of SHR (30 days old) treated or untreated with Atenolol during pregnancy and lactation. MMP-9 expression was evaluated in ameloblasts (AM), enamel matrix (EM), odontoblasts (OD), and predentin (PD) of IT through immunohistochemical reactions (immunoperoxidase). Data were analyzed by Shapiro-Wilk and Kruskal-Wallis (p < 0.05), with Dunn post-test. Histological differences were not observed between IT tissues of SHR and normotensive Wistar rats. For the first time, our data showed that MMP-9 expression in specific dental structures is not altered in SHR. Atenolol treatment increased MMP-9 immunostaining in EM of Wistar rat, however, Atenolol did not alter MMP-9 in the IT tissues of SHR. Our results demonstrated that MMP-9 expression in dental tissues is not affected by hypertension or atenolol treatment in dental tissues. If confirmed in humans, the results obtained in this study will corroborate the suggestion that MMP-9 is not a viable therapeutic target for the treatment of dental alterations associated with maternal hypertension.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Pediatric Dentistry and Public Health Juiz de Fora Dental School Universidade Federal de Juiz de Fora- UFJF, MG-
Descrição: dc.descriptionGraduate Program in Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry Department of Preventive and Restorative Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry Department of Basic Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionGraduate Program in Science School of Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry Department of Preventive and Restorative Dentistry São Paulo State University (UNESP), SP-
Descrição: dc.descriptionSchool of Dentistry Department of Basic Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: finance code 001-
Idioma: dc.languageen-
Relação: dc.relationJournal of Molecular Histology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAtenolol-
Palavras-chave: dc.subjectDental enamel-
Palavras-chave: dc.subjectDentin-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectMetalloproteinase-
Título: dc.titleMMP-9 expression in rat pup incisor teeth is not altered by maternal hypertension or maternal atenolol treatment during pregnancy and lactation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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