A Brief History of Cell Culture: From Harrison to Organs-on-a-Chip

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Western São Paulo-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.creatorMoro, Lincoln Gozzi-
Autor(es): dc.creatorGuarnier, Lucas Pires-
Autor(es): dc.creatorAzevedo, Maurício Fogaça-
Autor(es): dc.creatorFracasso, Julia Amanda Rodrigues-
Autor(es): dc.creatorLucio, Marco Aurélio-
Autor(es): dc.creatorCastro, Mateus Vidigal de-
Autor(es): dc.creatorDias, Marlon Lemos-
Autor(es): dc.creatorLívero, Francislaine Aparecida dos Reis-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu-
Data de aceite: dc.date.accessioned2025-08-21T22:32:23Z-
Data de disponibilização: dc.date.available2025-08-21T22:32:23Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/cells13242068-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306379-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306379-
Descrição: dc.descriptionThis comprehensive overview of the historical milestones in cell culture underscores key breakthroughs that have shaped the field over time. It begins with Wilhelm Roux’s seminal experiments in the 1880s, followed by the pioneering efforts of Ross Granville Harrison, who initiated groundbreaking experiments that fundamentally shaped the landscape of cell culture in the early 20th century. Carrel’s influential contributions, notably the immortalization of chicken heart cells, have marked a significant advancement in cell culture techniques. Subsequently, Johannes Holtfreter, Aron Moscona, and Joseph Leighton introduced methodological innovations in three-dimensional (3D) cell culture, initiated by Alexis Carrel, laying the groundwork for future consolidation and expansion of the use of 3D cell culture in different areas of biomedical sciences. The advent of induced pluripotent stem cells by Takahashi and Yamanaka in 2006 was revolutionary, enabling the reprogramming of differentiated cells into a pluripotent state. Since then, recent innovations have included spheroids, organoids, and organ-on-a-chip technologies, aiming to mimic the structure and function of tissues and organs in vitro, pushing the boundaries of biological modeling and disease understanding. In this review, we overview the history of cell culture shedding light on the main discoveries, pitfalls and hurdles that were overcome during the transition from 2D to 3D cell culture techniques. Finally, we discussed the future directions for cell culture research that may accelerate the development of more effective and personalized treatments.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)-
Descrição: dc.descriptionHuman Genome and Stem Cell Research Center Institute of Biosciences University of São Paulo—USP-
Descrição: dc.descriptionDepartment of Genetic Ribeirão Preto Medical School University of São Paulo—USP-
Descrição: dc.descriptionInstitute of Biomedical Sciences University of São Paulo—USP-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionGraduate Program in Environment and Regional Development University of Western São Paulo-
Descrição: dc.descriptionPrecision Medicine Research Center Carlos Chagas Filho Biophysics Institute Federal University of Rio de Janeiro—UFRJ-
Descrição: dc.descriptionLaboratory of Cardiometabolic Pharmacology Federal University of Paraná—UFPR-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy (GenTe Cel) Department of Biotechnology São Paulo State University—UNESP-
Descrição: dc.descriptionSchool of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy (GenTe Cel) Department of Biotechnology São Paulo State University—UNESP-
Descrição: dc.descriptionCNPq: 140520/2021-0-
Descrição: dc.descriptionCNPq: 170653/2023-4-
Idioma: dc.languageen-
Relação: dc.relationCells-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject2D cell culture-
Palavras-chave: dc.subject3D cell culture-
Palavras-chave: dc.subjectcell culture-
Palavras-chave: dc.subjectorganoids-
Palavras-chave: dc.subjectorgans-on-a-chip-
Palavras-chave: dc.subjectspheroids-
Título: dc.titleA Brief History of Cell Culture: From Harrison to Organs-on-a-Chip-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.