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| Metadados | Descrição | Idioma |
|---|---|---|
| Autor(es): dc.contributor | University of Milan | - |
| Autor(es): dc.contributor | Wroclaw University of Environmental and Life Sciences | - |
| Autor(es): dc.contributor | Wroclaw Medical University | - |
| Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
| Autor(es): dc.contributor | Universidade Paulista (UNIP) | - |
| Autor(es): dc.creator | Brambilla, Eleonora | - |
| Autor(es): dc.creator | Ciaputa, Rafał | - |
| Autor(es): dc.creator | Crepaldi, Paola | - |
| Autor(es): dc.creator | Dzimira, Stanislaw | - |
| Autor(es): dc.creator | Nowak, Marcin | - |
| Autor(es): dc.creator | Dziegiel, Piotr | - |
| Autor(es): dc.creator | Piotrowska, Aleksandra | - |
| Autor(es): dc.creator | Mollica Govoni, Veronica | - |
| Autor(es): dc.creator | Fonseca-Alves, Carlos Eduardo | - |
| Autor(es): dc.creator | Laufer-Amorim, Renée | - |
| Autor(es): dc.creator | Stefanello, Damiano | - |
| Autor(es): dc.creator | Romussi, Stefano | - |
| Autor(es): dc.creator | Grieco, Valeria | - |
| Data de aceite: dc.date.accessioned | 2025-08-21T18:22:07Z | - |
| Data de disponibilização: dc.date.available | 2025-08-21T18:22:07Z | - |
| Data de envio: dc.date.issued | 2025-04-29 | - |
| Data de envio: dc.date.issued | 2022-12-31 | - |
| Fonte completa do material: dc.identifier | http://dx.doi.org/10.3389/fvets.2023.1258247 | - |
| Fonte completa do material: dc.identifier | https://hdl.handle.net/11449/306356 | - |
| Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/306356 | - |
| Descrição: dc.description | The tumor microenvironment is considered one of the main players in cancer development and progression and may influence the behavior of cancer cells. Periostin (POSTN) is an extracellular matrix protein, and its main functions are induction of fibrillogenesis, fibroblastic cell proliferation and migration, enhancing regeneration in normal tissue, and promoting metastasis in case of neoplasia. POSTN has already been studied in humans in several normal tissues, inflammatory processes, and neoplasms, revealing an important role in tumor progression in various types of cancer, such as colon, lung, head and neck, breast, ovarian, and prostate. In these latter, high levels of POSTN are usually associated with a more aggressive tumor behavior, tumor advanced stages, and poor prognosis, while in human bladder urothelial carcinoma (BUC), unlike in most tumors, POSTN expression seems to be downregulated. The expression of this marker has been poorly investigated in veterinary medicine; thus, this study aimed to immunohistochemically investigate the presence and the intensity of POSTN expression in canine BUCs and to determine a possible relationship between POSTN expression and histopathological features such as mitotic count and muscular and vascular invasions. For the present retrospective study, archived samples from 45 canine BUCs and 6 non-neoplastic canine bladders were considered for histological evaluation and immunohistochemical examination for the expression of POSTN. POSTN expression was semi-quantitatively assessed considering both the percentage of the neoplastic stroma positive for POSTN and the intensity of the immunohistochemical labeling. Histologically, 38 out of 45 tumors were papillary and 7 out of 45 were non-papillary. All tumors were infiltrating, being that 21 were muscle-invasive, and a significant correlation between this feature and vascular invasion emerged (P = 0.0001). In normal bladder tissue, as reported in humans, a thick and strongly positive belt of POSTN was visible, and in canine BUCs, stating that the expression is comparable with human benign as well as malignant bladder tissue, a general decrease in POSTN expression was observed except for a strongly labeled ring of POSTN observed around some neoplastic nodules infiltrating the muscle layer. Moreover, POSTN expression and mitotic count were significatively inversely correlated (P = 0.0015). The fact that POSTN protein is less expressed in urothelial carcinomas than in the normal bladder supports what was reported in human BUCs and, together with the negative correlation between mitotic count and protein expression that emerged in the present retrospective study, encourages further prospective follow-up studies to verify the possible role of POSTN in canine BUCs as a prognostic marker, and also as a possible target for the development of future anticancer therapies. | - |
| Descrição: dc.description | Department of Veterinary Medicine and Animal Science University of Milan | - |
| Descrição: dc.description | Division of Pathomorphology and Veterinary Forensics Department of Pathology Faculty of Veterinary Medicine Wroclaw University of Environmental and Life Sciences | - |
| Descrição: dc.description | Department of Agricultural and Environmental Sciences - Production University of Milan, Agroenergy | - |
| Descrição: dc.description | Division of Histology and Embryology Department of Human Morphology and Embryology Wroclaw Medical University | - |
| Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Universidade Estadual Paulista (UNESP) | - |
| Descrição: dc.description | Institute of Health Sciences Universidade Paulista (UNIP) | - |
| Descrição: dc.description | Department of Veterinary Clinic Universidade Estadual Paulista (UNESP) | - |
| Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Universidade Estadual Paulista (UNESP) | - |
| Descrição: dc.description | Department of Veterinary Clinic Universidade Estadual Paulista (UNESP) | - |
| Idioma: dc.language | en | - |
| Relação: dc.relation | Frontiers in Veterinary Science | - |
| ???dc.source???: dc.source | Scopus | - |
| Palavras-chave: dc.subject | cancer associate fibroblasts (CAFs) | - |
| Palavras-chave: dc.subject | canine urothelial carcinoma | - |
| Palavras-chave: dc.subject | dog urothelial carcinoma | - |
| Palavras-chave: dc.subject | POSTN | - |
| Palavras-chave: dc.subject | urinary bladder | - |
| Título: dc.title | Canine urothelial carcinoma: expression of Periostin in spontaneous canine urothelial carcinoma and its correlation with histological features | - |
| Tipo de arquivo: dc.type | livro digital | - |
| Aparece nas coleções: | Repositório Institucional - Unesp | |
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