Impact of HPV Types and Dendritic Cells on Recurrent Respiratory Papillomatosis’ Aggressiveness

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCentro Clínico de Cabeza y Cuello-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorFernandes, Ellen Eduarda-
Autor(es): dc.creatorde Almeida Lança, Maria Leticia-
Autor(es): dc.creatorde Souza, Yan Aparecido-
Autor(es): dc.creatorEl-Achkar, Vivian Narana-
Autor(es): dc.creatorCosta, Victor-
Autor(es): dc.creatorCarlos, Román-
Autor(es): dc.creatorRibeiro-Silva, Alfredo-
Autor(es): dc.creatorSichero, Laura-
Autor(es): dc.creatorVilla, Luisa Lina-
Autor(es): dc.creatorLeón, Jorge Esquiche-
Autor(es): dc.creatorKaminagakura, Estela-
Data de aceite: dc.date.accessioned2025-08-21T15:15:41Z-
Data de disponibilização: dc.date.available2025-08-21T15:15:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/diseases13020043-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306330-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306330-
Descrição: dc.descriptionObjective: This study assesses the associations between dendritic cells, HPV 6 and 11, and Recurrent Respiratory Papillomatosis (RRP) aggressiveness. Methods: The Derkay score was calculated using information obtained from the medical records. Biopsies from 36 patients with juvenile RRP (JRRP) and 43 adult RRP (ARRP) patients were analyzed under light microscopy, and their clinical data were collected. Immunohistochemical analysis using antibodies against CD83, CD1a, Factor XIIIa, and S100 was performed, and inflammatory cells were quantified. Data obtained were analyzed using the chi-squared test, in addition to the Mann–Whitney and Z tests for two proportions, considering a confidence interval of 95% and p < 0.05 as statistically significant. Results: A higher quantity of S100 was identified in the epithelium (p < 0.001) and in the conjunctive tissue (p = 0.027) among the ARRP cases, while CD83 (p = 0.025) and Factor XIIIa (p = 0.018), both in the epithelium, were identified among the JRRP cases. We observed significant association between a higher quantity of CD83 in the epithelium in the juvenile group with a low Derkay index (p = 0.034) and with HPV 6 (p = 0.039). Conclusions: An increased quantity of dendritic cells is present in individuals diagnosed with RRP, regardless of age, and this may be related to the lower Derkay index, regardless of the HPV type detected.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University—UNESP-
Descrição: dc.descriptionCentro Clínico de Cabeza y Cuello-
Descrição: dc.descriptionDepartment of Pathology and Forensic Medicine Ribeirão Preto Medical School Universidade de São Paulo-
Descrição: dc.descriptionCenter for Translational Research in Oncology Instituto do Cancer do Estado de São Paulo Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Radiology and Oncology Faculdade de Medicina Universidade de São Paulo-
Descrição: dc.descriptionOral Pathology Department of Stomatology Public Oral Health and Forensic Dentistry School of Dentistry of Ribeirão Preto University of São Paulo, Ribeirão Preto-
Descrição: dc.descriptionDepartment of Bioscience and Oral Diagnosis Institute of Science and Technology São Paulo State University—UNESP-
Descrição: dc.descriptionFAPESP: 16/24019-0-
Idioma: dc.languageen-
Relação: dc.relationDiseases-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdendritic cells-
Palavras-chave: dc.subjecthuman papillomavirus virus-
Palavras-chave: dc.subjectinflammatory cells-
Palavras-chave: dc.subjectjuvenile laryngeal papillomatosis-
Palavras-chave: dc.subjectlaryngeal papillomatosis-
Título: dc.titleImpact of HPV Types and Dendritic Cells on Recurrent Respiratory Papillomatosis’ Aggressiveness-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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