Systemic ozone therapy as an adjunctive treatment in guided bone regeneration: a histomorphometrical and immunohistochemical study in rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBaggio, Ana Maira Pereira-
Autor(es): dc.creatorBizelli, Vinícius Ferreira-
Autor(es): dc.creatorDelamura, Izabela Fornazari-
Autor(es): dc.creatorViotto, Arthur Henrique Alecio-
Autor(es): dc.creatorVeras, Allice Santos Cruz-
Autor(es): dc.creatorTeixeira, Giovana Rampazzo-
Autor(es): dc.creatorFaverani, Leonardo Perez-
Autor(es): dc.creatorBassi, Ana Paula Farnezi-
Data de aceite: dc.date.accessioned2025-08-21T19:15:19Z-
Data de disponibilização: dc.date.available2025-08-21T19:15:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-024-05961-3-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306305-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306305-
Descrição: dc.descriptionObjectives: To assess the effectiveness of ozone therapy in guided bone regeneration (GBR) for critical size calvarial defects in rats. Materials and methods: 96 male Wistar rats were divided into four groups (n = 6 each). An 8 mm critical defect was created in the calvaria of each rat. The groups were: BIO (porcine collagen membrane, BioGide®), BIO + OZ (membrane with systemic ozone therapy every 2 days), COA + OZ (blood clot with ozone therapy), and COA (blood clot only). Evaluations at 7, 15, 30, and 60 days included histological, histomorphometric, inflammatory profile, Micro-CT, and immunohistochemical analyses. Statistical analysis involved two-factor ANOVA with Tukey’s post-hoc test for general data, and one-factor ANOVA with Holm-Sidak post-hoc test for Micro-CT data. Results: The BIO + OZ group demonstrated superior bone regeneration with well-organized, mature bone tissue and significant bone formation at 30 and 60 days. The COA + OZ group showed early angiogenesis and reduced inflammation, resulting in complete defect closure by 30 days. The BIO group had good regeneration, but less mature tissue compared to BIO + OZ. The COA group exhibited limited bone formation and higher porosity. Conclusion: Ozone therapy positively influences bone regeneration by enhancing cell proliferation and the healing response. Clinical relevance: Improving regenerative processes with auxiliary therapies like ozone therapy can be significant for advancing dental reconstructions.-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionMulticentric Postgraduate Program in Physiological Sciences - SBFis School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education School of Science and Technology São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionMulticentric Postgraduate Program in Physiological Sciences - SBFis School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Physical Education School of Science and Technology São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatible biomaterials-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectOzone-
Título: dc.titleSystemic ozone therapy as an adjunctive treatment in guided bone regeneration: a histomorphometrical and immunohistochemical study in rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.