Depth of invasion of oral squamous cell carcinoma in Nos2-knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment

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Autor(es): dc.contributorUniversidade Federal de Uberlândia (UFU)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Débora de Oliveira-
Autor(es): dc.creatorCosta, Anaíra Ribeiro Guedes Fonseca-
Autor(es): dc.creatorDuarte, Pedro Victor Silva-
Autor(es): dc.creatorPitorro, Tássio Edno Atanásio-
Autor(es): dc.creatorFonseca, Lúbia Cristina-
Autor(es): dc.creatorCardoso, Sérgio Vitorino-
Autor(es): dc.creatorde Faria, Paulo Rogério-
Autor(es): dc.creatorLoyola, Adriano Mota-
Data de aceite: dc.date.accessioned2025-08-21T19:24:06Z-
Data de disponibilização: dc.date.available2025-08-21T19:24:06Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jop.13523-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306216-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306216-
Descrição: dc.descriptionBackground: Peripheral blood analysis is a non-invasive and low-cost technique of prognostic value for several diseases, including oral cancer. Considering the role of inducible nitric oxide synthase in tumor-associated inflammation, this study purposed to evaluate the influence of this enzyme on peripheral blood parameters and systemic inflammatory biomarkers during murine oral carcinogenesis. Methods: A 50 μg/mL solution of 4-nitroquinoleine-N-oxide was provided to 15 C57BL/6J (Nos2+/+) and 16 B6.129P2-Nos2tm1Lau/J (Nos2−/−) for 16 weeks. Animals were followed for 8 weeks after treatment. Blood samples and tongues were collected for hematological and histopathological analyses. Red blood cells, white blood cells, and platelet cell parameters were analyzed. The neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and the systemic immune-inflammation index were also calculated. The depth of invasion of all carcinomas was measured. Results: Differences were found in several blood parameters. The depth of invasion in Nos2−/− was lower than in Nos2+/+ (p = 0.009), and strong correlations were found between depth of invasion and neutrophil count (ρ = −0.68, p = 0.017), lymphocyte count (ρ = 0.72, p = 0.011), neutrophil-to-lymphocyte ratio (ρ = −0.65, p = 0.025), platelet-to-lymphocyte ratio (ρ = −0.73, p = 0.013), and systemic immune-inflammation index (ρ = −0.67, p = 0.037) in Nos2−/− mice. Conclusion: Inducible nitric oxide synthase seems to have an important role in OSCC invasion and progression, which might be associated to alterations in immune-inflammatory cell dynamics evidenced by peripheral blood and systemic inflammatory biomarkers.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Pathology Federal University of Uberlândia, Minas Gerais-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Júlio de Mesquita Filho São Paulo State University-
Descrição: dc.descriptionDepartment of Periodontology Federal University of Uberlândia, Minas Gerais-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Júlio de Mesquita Filho São Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 409081-21-3-
Descrição: dc.descriptionFAPEMIG: APQ-3020/21-
Formato: dc.format208-216-
Idioma: dc.languageen-
Relação: dc.relationJournal of Oral Pathology and Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcarcinogenesis-
Palavras-chave: dc.subjecthematological tests-
Palavras-chave: dc.subjectnitric oxide-
Palavras-chave: dc.subjectoral cancer-
Palavras-chave: dc.subjecttumor biomarkers-
Título: dc.titleDepth of invasion of oral squamous cell carcinoma in Nos2-knockout mice correlated to alterations in systemic inflammatory markers following 4NQO treatment-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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