The Impact of Vertical Jump Exercise in the Postsynaptic Cleft in Wistar Rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRocha-Braga, Lara Caetano-
Autor(es): dc.creatorGomes, Isabella-
Autor(es): dc.creatorNeto, Jurandyr Pimentel-
Autor(es): dc.creatorTomiate, André Neri-
Autor(es): dc.creatorCamargo, Paula Oliveira-
Autor(es): dc.creatorda Silva, José Roberto Rodrigues-
Autor(es): dc.creatorCiena, Adriano Polican-
Data de aceite: dc.date.accessioned2025-08-21T20:12:59Z-
Data de disponibilização: dc.date.available2025-08-21T20:12:59Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.32098/mltj.03.2024.02-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306094-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306094-
Descrição: dc.descriptionBackground. Skeletal muscle tissue demonstrates remarkable adaptability responding to stimuli at the neuromuscular junction (NMJ) during activities like vertical jumping, an essential ability in sports. Research about these changes can offer insights into neuromuscular plasticity. Objective. The study aimed to explore the neuroplasticity of the postsynaptic cleft at the NMJ after vertical jump (VJ) training in twenty 90-day-old male Wistar rats, divided into Sedentary (S) and Jumper (J) groups. Methods. A combination of immunostaining and microscopy was used to analyze structural and functional changes at the NMJ. α-Bungarotoxin highlighted the postsynaptic components, while fluorescence microscopy detailed the tissue and NMJ structures. Statistical analyses, including the Mann-Whitney test and the Shapiro-Wilk test, were used to compare groups and test data normality, with a significance level of p < 0.05 to ensure the relevance of the results. Results. The morphometric analysis of the NMJ showed that the J group had a smaller postsynaptic cleft compared to the S group. There were no significant differences in dispersion, AChR area, endplate area, or endplate perimeter between the groups but lower values in J Group (p < 0.05). However, the AChR perimeter was significantly lower in the J group (p < 0.05). Additionally, the J group had fewer AChR clusters and a lower fragmentation index, both significantly different (p < 0.005). Conclusions. VJ training modifies the NMJ affecting the organization and morphology of the motor endplate. This underscores the role of physical exercise in neuromuscular remodeling and calls for further studies to understand the functional implications of these adaptations.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2020/074184-
Formato: dc.format396-401-
Idioma: dc.languageen-
Relação: dc.relationMuscles, Ligaments and Tendons Journal-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectneuromuscular junction-
Palavras-chave: dc.subjectneuroplasticity vertical jump-
Palavras-chave: dc.subjectα-bungarotoxin-
Título: dc.titleThe Impact of Vertical Jump Exercise in the Postsynaptic Cleft in Wistar Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.