Glucose utilization by the trained heart: the molecular mechanisms behind fuel choice

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Autor(es): dc.contributorFaculty of Medicine of the University of Porto-
Autor(es): dc.contributorUniversity of Porto (FADE/UP)-
Autor(es): dc.contributorLaboratory for Integrative and Translational Research in Population Health (ITR)-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorCentro Hospitalar Universitário de Santo António (CHUdSA)-
Autor(es): dc.contributorCentro Hospitalar Universitário de São João-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCIDAF-
Autor(es): dc.contributorUniversity of Aveiro-
Autor(es): dc.creatorNogueira-Ferreira, Rita-
Autor(es): dc.creatorMoreira-Gonçalves, Daniel-
Autor(es): dc.creatorSantos, Mário-
Autor(es): dc.creatorLeite-Moreira, Adelino-
Autor(es): dc.creatorLira, Fabio Santos-
Autor(es): dc.creatorFerreira, Rita-
Data de aceite: dc.date.accessioned2025-08-21T21:02:54Z-
Data de disponibilização: dc.date.available2025-08-21T21:02:54Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/B978-0-323-91704-9.00015-X-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306091-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306091-
Descrição: dc.descriptionThe heart is capable of using all types of substrates to meet the energetic demands made by the contraction function, and it adjusts its substrate utilization in response to environmental alterations. Glucose is the preferred fuel during stress conditions such as ischemia and adrenergic stimulation. In addition to glycolysis as an energy-producing pathway, other pathways related to glucose metabolism, such as the hexosamine biosynthetic pathway and pentose phosphate pathway, also support the metabolic and functional needs of the heart.The cardiac beneficial effects of exercise training are undisputedly recognized. Exercise training has been recommended for cardiovascular disease prevention and treatment. However, the understanding of the metabolic pathways associated with these effects remains a topic of research. This has been a challenge since the physiological response to exercise training is dependent on the intensity, duration, frequency, and type of exercise as well as the environmental conditions. However, the knowledge of the metabolic adaptations of the heart to exercise training not only can contribute to a better comprehension of the molecular mechanisms associated with exercise training effects but can also provide clues to novel therapeutic targets.This chapter overviews glucose metabolism in the heart and highlights the role of glycolysis and its regulation of the cardiac remodeling induced by exercise training.-
Descrição: dc.descriptionCardiovascular R&D Centre—UnIC@RISE Department of Surgery and Physiology Faculty of Medicine of the University of Porto-
Descrição: dc.descriptionResearch Centre in Physical Activity Health and Leisure (CIAFEL) Faculty of Sport University of Porto (FADE/UP)-
Descrição: dc.descriptionLaboratory for Integrative and Translational Research in Population Health (ITR)-
Descrição: dc.descriptionUMIB-Unit for Multidisciplinary Research in Biomedicine ICBAS-School of Medicine and Biomedical Sciences University of Porto-
Descrição: dc.descriptionDepartment of Cardiology Centro Hospitalar Universitário de Santo António (CHUdSA)-
Descrição: dc.descriptionDepartment of Cardiothoracic Surgery Centro Hospitalar Universitário de São João-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionFaculty of Sport Science and Physical Education University of Coimbra CIDAF-
Descrição: dc.descriptionLAQV-REQUIMTE Department of Chemistry University of Aveiro-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Formato: dc.format75-90-
Idioma: dc.languageen-
Relação: dc.relationGlycolysis: Tissue-Specific Metabolic Regulation in Physio-pathological Conditions-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectExercise training-
Palavras-chave: dc.subjectglycolysis-
Palavras-chave: dc.subjectheart-
Palavras-chave: dc.subjectlactate-
Palavras-chave: dc.subjectmetabolic signaling-
Título: dc.titleGlucose utilization by the trained heart: the molecular mechanisms behind fuel choice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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