Maternal protein restriction combined with postnatal sugar consumption alters liver proteomic profile and metabolic pathways in adult male offspring rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFox Chase Cancer Center-
Autor(es): dc.contributorFederal University of Maranhão-
Autor(es): dc.contributorSalvador Zubirán National Institute of Medical Sciences and Nutrition-
Autor(es): dc.contributorUniversidad Nacional Autónoma de Mexico-
Autor(es): dc.creatorRibeiro, Isabelle Tenori-
Autor(es): dc.creatorFioretto, Matheus Naia-
Autor(es): dc.creatordos Santos, Sérgio Alexandre Alcantara-
Autor(es): dc.creatorColombelli, Ketlin Thassiani-
Autor(es): dc.creatorPortela, Luiz Marcos Frediani-
Autor(es): dc.creatorNiz Alvarez, Marcus Vinicius-
Autor(es): dc.creatorde Magalhães Padilha, Pedro-
Autor(es): dc.creatorDelgado, Aislan Quintiliano-
Autor(es): dc.creatorMarques, Marcus Vinicius Lage Silva Giaculi-
Autor(es): dc.creatorBosqueiro, José Roberto-
Autor(es): dc.creatorSeiva, Fábio Rodrigues Ferreira-
Autor(es): dc.creatorBarbisan, Luís Fernando-
Autor(es): dc.creatorde Andrade Paes, Antonio Marcus-
Autor(es): dc.creatorZambrano, Elena-
Autor(es): dc.creatorJustulin, Luis Antonio-
Data de aceite: dc.date.accessioned2025-08-21T22:55:34Z-
Data de disponibilização: dc.date.available2025-08-21T22:55:34Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2024.112316-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306070-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306070-
Descrição: dc.descriptionThis study investigated the impact of maternal protein restriction (MPR) and early postnatal sugar consumption (SUG) on the liver health of adult male descendant rats. Male offspring of mothers fed a normal protein diet (NPD) or a low protein diet (LPD) were divided into four groups: Control (CTR), Sugar Control (CTR + SUG), LPD during gestation and lactation (GLLP), and LPD with sugar (GLLP + SUG). Sugar consumption (10% glucose diluted in water) began after weaning on day 21 (PND 21), and at 90 days (PND 90), rats were sacrificed for analysis. Sugar intake reduced food intake and increased water consumption in CTR + SUG and GLLP + SUG compared to CTR and GLLP. GLLP and GLLP + SUG groups showed lower body weight and total and retroperitoneal fat compared to CTR and CTR + SUG. CTR + SUG and GLLP + SUG groups exhibited hepatocyte vacuolization associated with increased hepatic glycogen content compared to CTR and GLLP. Hepatic catalase activity increased in GLLP compared to CTR. Proteomic analysis identified 223 differentially expressed proteins (DEPs) among experimental groups. While in the GLLP group, the DEPs enriched molecular pathways related to cellular stress, glycogen metabolic pathways were enriched in the GLLP + SUG and CTR + SUG groups. The association of sugar consumption amplifies the effects of MPR, deregulating molecular mechanisms related to metabolism and the antioxidant system.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUNESP- Sao Paulo State University Department of Structural and Functional Biology Institute of Biosciences, SP-
Descrição: dc.descriptionCancer Signaling and Epigenetics Program Fox Chase Cancer Center-
Descrição: dc.descriptionBiotechnology Institute and Bioscience Institute Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Physical Education Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Physiological Sciences Federal University of Maranhão, São Luiz, MA-
Descrição: dc.descriptionDepartment Reproductive Biology Salvador Zubirán National Institute of Medical Sciences and Nutrition-
Descrição: dc.descriptionFacultad de Química Universidad Nacional Autónoma de Mexico-
Descrição: dc.descriptionUNESP- Sao Paulo State University Department of Structural and Functional Biology Institute of Biosciences, SP-
Descrição: dc.descriptionBiotechnology Institute and Bioscience Institute Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Physical Education Institute of Biosciences Sao Paulo State University, SP-
Descrição: dc.descriptionDepartment of Chemical and Biological Sciences Institute of Biosciences Sao Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectLiver-
Palavras-chave: dc.subjectMaternal protein restriction-
Palavras-chave: dc.subjectMetabolism-
Palavras-chave: dc.subjectProteomic-
Palavras-chave: dc.subjectSugar consumption-
Título: dc.titleMaternal protein restriction combined with postnatal sugar consumption alters liver proteomic profile and metabolic pathways in adult male offspring rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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