The interplay between extracellular NAMPT and inflammatory cytokines in preeclampsia

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorNunes, Priscila Rezeck-
Autor(es): dc.creatorPereira, Daniela Alves-
Autor(es): dc.creatorPasseti, Luis Fernando Pereira-
Autor(es): dc.creatorCoura, Lídia Lana Ferreira-
Autor(es): dc.creatorGomes, Karina Braga-
Autor(es): dc.creatorSandrim, Valeria Cristina-
Autor(es): dc.creatorLuizon, Marcelo Rizzatti-
Data de aceite: dc.date.accessioned2025-08-21T22:58:07Z-
Data de disponibilização: dc.date.available2025-08-21T22:58:07Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jri.2024.104248-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/306037-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/306037-
Descrição: dc.descriptionPreeclampsia (PE) is the major cause of maternal-fetal mortality and morbidity. Its pathophysiology is not elucidated, but there is evidence for the role of visfatin/nicotinamide phosphoribosyl transferase (NAMPT), mainly due to its relation to endothelial dysfunction, a hallmark of PE. However, there is heterogeneous data regarding visfatin/NAMPT in healthy pregnancy (HP) and PE. Therefore, we performed a search on MEDLINE/PubMed using the terms “visfatin and preeclampsia” and “NAMPT and preeclampsia, and we selected 23 original articles: 12 articles reported increased levels in PE compared to HP, only four articles showed lower levels and eight articles did not find differences regarding visfatin/NAMPT in the groups studied. It is widely acknowledged that levels detected in plasma, serum, or placenta can be influenced by the size of the population and sample analyzed, as well as genetic factors. We further discussed the correlations of visfatin/NAMPT with clinical biomarkers in PE and inflammatory pathways. Considering the common inflammatory mechanisms between PE and visfatin/NAMPT, few studies have recently performed serum or plasma dosages. In conclusion, further studies are needed to highlight the potential role of visfatin/NAMPT in the pathophysiology of PE. This will provide comparative evidence to establish it as a biomarker for disease outcomes and treatment.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
Descrição: dc.descriptionDepartment of Pharmacology and Biophysics Institute of Biosciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionDepartment of Genetics Ecology and Evolution Institute of Biological Sciences Federal University of Minas Gerais (UFMG), Minas Gerais-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analysis Federal University of Minas Gerais (UFMG), Minas Gerais-
Descrição: dc.descriptionDepartment of Pharmacology and Biophysics Institute of Biosciences Sao Paulo State University (Unesp)-
Descrição: dc.descriptionFAPESP: 2019/07230-8-
Descrição: dc.descriptionFAPESP: 2020/14610-9-
Descrição: dc.descriptionCNPq: 308504/2021-6-
Descrição: dc.descriptionFAPEMIG: APQ-01960-18-
Idioma: dc.languageen-
Relação: dc.relationJournal of Reproductive Immunology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCytokines-
Palavras-chave: dc.subjectEndothelial dysfunction-
Palavras-chave: dc.subjectExtracellular nicotinamide phosphoribosyltransferase (eNAMPT)-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNicotinamide phosphoribosyl transferase-
Palavras-chave: dc.subjectToll-like receptor-
Palavras-chave: dc.subjectVisfatin/NAMPT-
Título: dc.titleThe interplay between extracellular NAMPT and inflammatory cytokines in preeclampsia-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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