Effects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats

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Autor(es): dc.contributorUniversidade Federal de São Paulo (UNIFESP)-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorUniversidade Federal de Alfenas-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGarnevi-Fávero, Aline-
Autor(es): dc.creatorSilva, Karina Nascimento-da-
Autor(es): dc.creatorRodrigues-Ribeiro, Willian-
Autor(es): dc.creatorMarcantonio-Ferreira, Caroline-
Autor(es): dc.creatorSartorelli, Patrícia-
Autor(es): dc.creatorCardili, Leonardo-
Autor(es): dc.creatorde Cássia-Sinigaglia, Rita-
Autor(es): dc.creatorBertaglia-Pereira, Joice Naiara-
Autor(es): dc.creatorSilva, Marcelo Aparecido-da-
Autor(es): dc.creatorVilegas, Wagner-
Autor(es): dc.creatorDias-Silva, Marcelo José-
Autor(es): dc.creatorRibeiro-Paiotti, Ana Paula-
Data de aceite: dc.date.accessioned2025-08-21T22:04:21Z-
Data de disponibilização: dc.date.available2025-08-21T22:04:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2022-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.7705/biomedica.6611-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305899-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305899-
Descrição: dc.descriptionIntroduction. Anti-inflammatories, immunosuppressants, and immunobiological are commonly used in the treatment of inflammatory bowel disease. However, some patients do not present an adequate response or lose effective response during the treatment. A recent study found a potential anti-inflammatory effect of the hydroalcoholic extract of Mimosa caesalpiniifolia on trinitrobenzene sulfonic acid-induced colitis in Wistar rats. Objective. To evaluate the effects of M. caesalpiniifolia pre-formulation on the intestinal barrier using dextran sulfate sodium-induced colitis model. Materials and methods. Leaf extracts were prepared in 70% ethanol and dried with a Buchi B19 Mini-spray dryer using 20% Aerosil® solution. Thirty-two male Wistar rats were randomized into four groups: basal control, untreated colitis, pre-formulation control (125 mg/kg/day), and colitis treated with pre-formulation (125 mg/kg/day). Clinical activity index was recorded daily and all rats were euthanized on the ninth day. Colon fragments were fixed and processed for histological and ultrastructural analyses. Stool samples were collected and processed for analysis of the short-chain fatty acid. Results. Treatment with the pre-formulation decreased the clinical activity (bloody diarrhea), inflammatory infiltrate, and the ulcers. Pre-formulation did not repair the epithelial barrier and there were no significant differences in the goblet cells index. There was a significant difference in butyrate levels in the rats treated with the pre-formulation. Conclusions. The pre-formulation minimized the clinical symptoms of colitis and intestinal inflammation, but did not minimize damage to the intestinal barrier.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Hepatology Molecular Applied Discipline of Gastroenterology Universidade Federal de São Paulo-
Descrição: dc.descriptionInstitute of Environmental Chemistry and Pharmaceutical Sciences Department of Pharmaceutics Sciences Universidade Federal de São Paulo-
Descrição: dc.descriptionLaboratory of Experimental and Molecular Pathology Department of Pathology Universidade Federal de São Paulo-
Descrição: dc.descriptionElectron Microscopy Centre Universidade Federal de São Paulo-
Descrição: dc.descriptionButantan Institute-
Descrição: dc.descriptionPharmacognosy Laboratory Universidade Federal de Alfenas, Minas Gerais-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Paulo-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, São Paulo-
Descrição: dc.descriptionCNPq: 2015/21479-8-
Formato: dc.format282-295-
Idioma: dc.languageen-
Idioma: dc.languagees-
Relação: dc.relationBiomedica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcolitis-
Palavras-chave: dc.subjectherbal medicine-
Palavras-chave: dc.subjectinflammatory bowel diseases-
Palavras-chave: dc.subjectMimosa-
Palavras-chave: dc.subjectulcerative-
Título: dc.titleEffects of Mimosa caesalpiniifolia pre-formulation on the intestinal barrier during sodium dextran sulfate-induced colitis in Wistar rats-
Título: dc.titleEfectos de la preformulación de Mimosa caesalpiniifolia sobre la barrera intestinal durante la colitis inducida por sulfato de dextrano sódico en ratas Wistar-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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