The Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorUnited Colleges of Northern Minas (FUNORTE)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.creatorNunes, Gabriel Pereira-
Autor(es): dc.creatorSilveira, Thayná Cerqueira-
Autor(es): dc.creatorMarciano, João Vítor Silveira-
Autor(es): dc.creatordos Reis-Prado, Alexandre Henrique-
Autor(es): dc.creatorFerrisse, Tulio Morandin-
Autor(es): dc.creatordos Anjos, Evandro Barbosa-
Autor(es): dc.creatorFernandes, Maria Helena-
Data de aceite: dc.date.accessioned2025-08-21T19:14:37Z-
Data de disponibilização: dc.date.available2025-08-21T19:14:37Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms25021247-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305826-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305826-
Descrição: dc.descriptionThis systematic review and meta-analysis evaluated the efficacy of dexlansoprazole (a proton pump inhibitor—PPI) in resolving heartburn, reflux, and other symptoms and complications resulting from gastroesophageal reflux disease (GERD). The study followed PRISMA 2020 and was registered in PROSPERO (CRD42020206513). The search strategy used MeSH and free terms appropriately adapted for each database. Only randomized clinical trials (RCTs) were included. The Cochrane tool (RoB 2.0) was used to assess the risk of bias, and the certainty of evidence was rated using GRADE. Ten RCTs were included. Dexlansoprazole outperformed the placebo and other PPIs in the resolution of heartburn and reflux symptoms in patients with GERD, with benefits during and after treatment, especially in those with moderate and severe symptoms. The meta-analyses indicated that dexlansoprazole at doses of 30 and 60 mg had more 24 h heartburn-free days and nights compared to the placebo medications; no difference was reported between dexlansoprazole at doses of 30 and 60 mg in heartburn-free nights. A low bias risk and a moderate certainty of evidence were observed. This review confirms the therapeutic effect of dexlansoprazole (placebo-controlled) and its improvements in GERD symptoms compared to another PPI. However, the interpretation of the results should be carried out cautiously due to the small number of included studies and other reported limitations.-
Descrição: dc.descriptionDepartment of Restorative and Preventive Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory for Bone Metabolism and Regeneration Faculty of Dental Medicine University of Porto-
Descrição: dc.descriptionAssociated Laboratory for Green Chemistry—LAQV/REQUIMTE University of Porto-
Descrição: dc.descriptionDepartment of Medicine Institute of Health Sciences (ICS) United Colleges of Northern Minas (FUNORTE)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionCariology Restorative Sciences and Endodontics School of Dentistry University of Michigan-
Descrição: dc.descriptionDepartment of Diagnosis Surgery and Oral Medicine School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative and Preventive Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Diagnosis Surgery and Oral Medicine School of Dentistry São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectdexlansoprazole-
Palavras-chave: dc.subjectgastroesophageal reflux-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectPPI-
Palavras-chave: dc.subjectsystematic review-
Título: dc.titleThe Effect of Dexlansoprazole on Gastroesophageal Reflux Disease: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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