Non-invasive biomagnetic assessment of gastrointestinal motility in a loperamide-induced constipation model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUFMT-
Autor(es): dc.creatorStoppa, Erick Guilherme-
Autor(es): dc.creatorSoares, Guilherme Augusto-
Autor(es): dc.creatorBuranello, Lais Pereira-
Autor(es): dc.creatorPortela, Luiz Marcos Frediani-
Autor(es): dc.creatorJustulin, Luiz Antônio-
Autor(es): dc.creatorAmérico, Madileine Francely-
Autor(es): dc.creatorDi Stasi, Luiz Claudio-
Autor(es): dc.creatorMiranda, José Ricardo de Arruda-
Data de aceite: dc.date.accessioned2025-08-21T21:49:40Z-
Data de disponibilização: dc.date.available2025-08-21T21:49:40Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/s2175-97902024e23717-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305817-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305817-
Descrição: dc.descriptionConstipation is a disorder of the gastrointestinal (GI) and some of the main etiological mechanisms are directly related to changes in GI physiology. The capacity to carry out paired assessments and measure GI parameters under the influence of constipation is a relevant point in selecting a suitable methodology. We aimed to perform a non-invasive investigation of gastrointestinal motility in constipated rats using the alternating current biosusceptometry system (ACB). The animals were split into two groups: the pre-induction stage (CONTROL) and post-induction loperamide stage (LOP). We assessed GI motility parameters using the ACB system. Colon morphometric and immunohistochemical analyses were performed for biomarkers (C-kit) for interstitial cells of Cajal (ICC). Our results showed a significant increase in gastrointestinal transit in the LOP group in addition to a reduction in the dominant frequency of gastric contraction and an arrhythmic profile. A change in colonic contractility profiles was observed, indicating colonic dysmotility in the LOP group. We found a reduction in the number of biomarkers for intestinal cells of Cajal (ICC) in the LOP group. The ACB system can evaluate transit irregularities and their degrees of severity, while also supporting research into novel, safer, and more efficient treatments for constipation.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Strucutral and Functional Biology Institute of Biosciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionInstitute of Biological Sciences and Health Federal University of Mato Grosso UFMT-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionDepartment of Strucutral and Functional Biology Institute of Biosciences São Paulo State University UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlternating Current Biosusceptometry (ACB)-
Palavras-chave: dc.subjectColonic Motility-
Palavras-chave: dc.subjectConstipation-
Palavras-chave: dc.subjectGastrointestinal Transit-
Palavras-chave: dc.subjectLoperamide-
Título: dc.titleNon-invasive biomagnetic assessment of gastrointestinal motility in a loperamide-induced constipation model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.