Adaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti

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Autor(es): dc.contributorUniversity of Pavia-
Autor(es): dc.contributorLeipzig University-
Autor(es): dc.contributorUniversity of Melbourne-
Autor(es): dc.contributorJimma University-
Autor(es): dc.contributorVirginia Polytechnic Institute and State University-
Autor(es): dc.contributorUniversité Joseph Ki-Zerbo-
Autor(es): dc.contributorMahidol University-
Autor(es): dc.contributorInstituto Nacional de Salud Pública-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCNRS UMR2000-
Autor(es): dc.contributorHuman Technopole-
Autor(es): dc.contributorThe Rockefeller University-
Autor(es): dc.contributorIrvine-
Autor(es): dc.contributorKansas State University-
Autor(es): dc.creatorLozada-Chávez, Alejandro N.-
Autor(es): dc.creatorLozada-Chávez, Irma-
Autor(es): dc.creatorAlfano, Niccolò-
Autor(es): dc.creatorPalatini, Umberto-
Autor(es): dc.creatorSogliani, Davide-
Autor(es): dc.creatorElfekih, Samia-
Autor(es): dc.creatorDegefa, Teshome-
Autor(es): dc.creatorSharakhova, Maria V.-
Autor(es): dc.creatorBadolo, Athanase-
Autor(es): dc.creatorSriwichai, Patchara-
Autor(es): dc.creatorCasas-Martínez, Mauricio-
Autor(es): dc.creatorCarlos, Bianca C.-
Autor(es): dc.creatorCarballar-Lejarazú, Rebeca-
Autor(es): dc.creatorLambrechts, Louis-
Autor(es): dc.creatorSouza-Neto, Jayme A.-
Autor(es): dc.creatorBonizzoni, Mariangela-
Data de aceite: dc.date.accessioned2025-08-21T17:45:05Z-
Data de disponibilização: dc.date.available2025-08-21T17:45:05Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41559-025-02643-5-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305814-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305814-
Descrição: dc.descriptionIn the arboviral vector Aedes aegypti, adaptation to anthropogenic environments has led to a major evolutionary shift separating the domestic Aedes aegypti aegypti (Aaa) ecotype from the wild Aedes aegypti formosus (Aaf) ecotype. Aaa mosquitoes are distributed globally and have higher vectorial capacity than Aaf, which remained in Africa. Despite the evolutionary and epidemiological relevance of this separation, inconsistent morphological data and a complex population structure have hindered the identification of genomic signals distinguishing the two ecotypes. Here we assessed the correspondence between the geographic distribution, population structure and genome-wide selection of 511 Aaf and 123 Aaa specimens and report adaptive signals in 186 genes that we call Aaa molecular signatures. Our results indicate that Aaa molecular signatures arose from standing variation associated with extensive ancestral polymorphisms in Aaf populations and have been co-opted for self-domestication through genomic and functional redundancy and local adaptation. Overall, we show that the behavioural shift of Ae. aegypti mosquitoes to live in association with humans relied on the fine regulation of chemosensory, neuronal and metabolic functions, as seen in the domestication processes of rabbits and silkworms. Our results also provide a foundation for the investigation of new genic targets for the control of Ae. aegypti populations.-
Descrição: dc.descriptionDepartment of Biology and Biotechnology University of Pavia-
Descrição: dc.descriptionEvo-devo Bioinformatics and Neuromorphic Information Processing groups Institute of Computer Science and Faculty of Mathematics and Computer Science Leipzig University-
Descrição: dc.descriptionAustralian Centre for Disease Preparedness CSIRO Australia Bio21 Institute School of Biosciences University of Melbourne-
Descrição: dc.descriptionSchool of Medical Laboratory Sciences Institute of Health Jimma University-
Descrição: dc.descriptionDepartment of Entomology and the Fralin Life Science Institute Virginia Polytechnic Institute and State University-
Descrição: dc.descriptionLaboratoire d’Entomologie Fondamentale et Appliquée Université Joseph Ki-Zerbo-
Descrição: dc.descriptionDepartment of Medical Entomology Faculty of Tropical Medicine Mahidol University-
Descrição: dc.descriptionCentro Regional de Investigación en Salud Pública Instituto Nacional de Salud Pública-
Descrição: dc.descriptionSchool of Agricultural Sciences São Paulo State University-
Descrição: dc.descriptionInsect–Virus Interactions Unit Institut Pasteur Université Paris Cité CNRS UMR2000-
Descrição: dc.descriptionHuman Technopole-
Descrição: dc.descriptionLaboratory of Neurogenetics and Behavior The Rockefeller University-
Descrição: dc.descriptionResearch Group on Integrated Pest Management School of Agronomy Crop Protection Department São Paulo State University-
Descrição: dc.descriptionDepartment of Microbiology and Molecular Genetics University of California Irvine-
Descrição: dc.descriptionCollege of Veterinary Medicine Kansas State University-
Descrição: dc.descriptionSchool of Agricultural Sciences São Paulo State University-
Descrição: dc.descriptionResearch Group on Integrated Pest Management School of Agronomy Crop Protection Department São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationNature Ecology and Evolution-
???dc.source???: dc.sourceScopus-
Título: dc.titleAdaptive genomic signatures of globally invasive populations of the yellow fever mosquito Aedes aegypti-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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