Cutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study

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Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul-
Autor(es): dc.contributorUniversidade Federal de Lavras (UFLA)-
Autor(es): dc.contributorUniversidade Federal da Bahia (UFBA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSantos, Bárbara Chaves-
Autor(es): dc.creatorAlves, Bruna Cherubini-
Autor(es): dc.creatorFonseca, Ana Luisa Ferreira-
Autor(es): dc.creatorFerreira, Samanta Catherine-
Autor(es): dc.creatorMizubuti, Yani Gláucia Gomide-
Autor(es): dc.creatorSaueressig, Camila-
Autor(es): dc.creatorBoulhosa, Ramona Souza da Silva Baqueiro-
Autor(es): dc.creatorSantos, Lívia Alves Amaral-
Autor(es): dc.creatorCunha, Carla de Magalhães-
Autor(es): dc.creatorLyra, Andre Castro-
Autor(es): dc.creatorOliveira, Lucivalda Pereira Magalhães-
Autor(es): dc.creatorde Jesus, Rosângela Passos-
Autor(es): dc.creatorRomeiro, Fernando Gomes-
Autor(es): dc.creatorDall’Alba, Valesca-
Autor(es): dc.creatorLuft, Vivian Cristine-
Autor(es): dc.creatorCorreia, Maria Isabel Toulson Davisson-
Autor(es): dc.creatorFerreira, Lívia Garcia-
Autor(es): dc.creatorAnastácio, Lucilene Rezende-
Data de aceite: dc.date.accessioned2025-08-21T18:47:58Z-
Data de disponibilização: dc.date.available2025-08-21T18:47:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41430-024-01563-0-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305812-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305812-
Descrição: dc.descriptionObjectives: This study aimed to define handgrip strength (HGS) cutoff points to predict 1-year mortality in adult patients with liver cirrhosis. Methods: This is an analysis of cohort databases from four reference centers in Brazil. Inpatients or outpatients with cirrhosis and aged ≥18 years were included. The best cutoff values of HGS (highest value from three attempts with the non-dominant hand) for predicting 1-year mortality, stratified by sex and age, were established based on the sensitivity and specificity analyses. Adjusted Cox regression models were used to test the predictive value of low HGS. Results: The study included 724 patients with cirrhosis, with a median age of 57.0 years (IQR: 50.0–63.0), 66.4% (n = 481) male. Most patients had alcoholic cirrhosis (n = 281; 38.8%), 400 (55.3%) were classified as Child-Pugh B or C, and 134 (18.5%) patients died after 1-year. The HGS cutoffs were ≤33 kgf and ≤12 kgf for men and women aged <60 years, respectively, and ≤22 kgf and ≤10 kgf for older men and women, respectively (sensitivity: 70.9%; specificity: 61.2%). Low HGS was associated with a 2.5-fold increase in the risk of 1-year mortality. Conclusion: These cutoff points could be used to identify patients with a higher mortality risk. (Figure presented.)-
Descrição: dc.descriptionFood Science Graduate Program Universidade Federal de Minas Gerais-
Descrição: dc.descriptionGastroenterology and Hepatology Graduate Program Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionNutrition and Health Graduate Program Universidade Federal de Lavras-
Descrição: dc.descriptionFood Nutrition and Health Graduate Program Universidade Federal da Bahia-
Descrição: dc.descriptionGastroenterology Division Department of Internal Medicine Universidade Estadual Paulista-
Descrição: dc.descriptionGastro-Hepatology Service Hospital Universitario Prof. Edgard Santos Universidade Federal da Bahia-
Descrição: dc.descriptionFood Nutrition and Health Graduate Program Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionEpidemiology Graduate Program Universidade Federal do Rio Grande do Sul-
Descrição: dc.descriptionSurgery Graduate Program Universidade Federal de Minas Gerais-
Descrição: dc.descriptionGastroenterology Division Department of Internal Medicine Universidade Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationEuropean Journal of Clinical Nutrition-
???dc.source???: dc.sourceScopus-
Título: dc.titleCutoff points for handgrip strength in patients with liver cirrhosis: a multicenter study-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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