Toward a More Sustainable Sample Preparation in Phytochemistry: Case Studies in Four Subclasses of Alkaloids

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKiel University-
Autor(es): dc.contributorHamburg University of Applied Sciences-
Autor(es): dc.contributorUniversity of Münster-
Autor(es): dc.creatorChibli, Lucas Apolinário-
Autor(es): dc.creatorde Lima, Bruna Ribeiro-
Autor(es): dc.creatorCarneiro, Ariadne Magalhães-
Autor(es): dc.creatorFigueiró, Harley Cardoso-
Autor(es): dc.creatorCicek, Serhat Sezai-
Autor(es): dc.creatorSpiegler, Verena-
Autor(es): dc.creatorFunari, Cristiano Soleo-
Data de aceite: dc.date.accessioned2025-08-21T16:48:18Z-
Data de disponibilização: dc.date.available2025-08-21T16:48:18Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-22-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.3c01048-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305806-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305806-
Descrição: dc.descriptionThe fact that alkaloids are bases has been the most explored chemical feature of their extraction and purification procedures. The main drawback of these procedures is that they employ undesirable chemicals, with HCl and CH2Cl2 probably being the most commonly employed chemicals in their subsequent steps. This work tested the hypothesis that advantages in recovery efficiency support this common practice. Experiments were conducted in three laboratories, monitoring the alkaloids harmine (1), boldine (2), vincamine (3), and mescaline (4) extracted from Banisteriopsis caapi, Peumus boldus, Vinca minor, and Trichocereus macrogonus var. pachanoi, respectively. The research demonstrated that HCl could be replaced with citric acid (CA) without loss or even better extraction performance. The recommended EtOAc could completely replace CH2Cl2 in three out of four study cases and partially in the fourth case without harming the extraction efficiency. In addition, the alternative solvents tert-amyl methyl ether (TAME) and n-butyl acetate (BuOAc) could enhance the extraction of alkaloids. These results might incentivize natural products laboratories to consider sustainability more routinely, thus being closer to current practices in the pharmaceutical industry, which has been replacing solvents and processes with greener ones.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pharmaceutical Biology Kiel University, Gutenbergstrase 76-
Descrição: dc.descriptionDepartment of Biotechnology Hamburg University of Applied Sciences, Ulmentliet 20-
Descrição: dc.descriptionInstitute of Pharmaceutical Biology and Phytochemistry University of Münster-
Descrição: dc.descriptionGreen Biotech Network School of Agricultural Sciences São Paulo State University (UNESP)-
Formato: dc.format470-479-
Idioma: dc.languageen-
Relação: dc.relationJournal of Natural Products-
???dc.source???: dc.sourceScopus-
Título: dc.titleToward a More Sustainable Sample Preparation in Phytochemistry: Case Studies in Four Subclasses of Alkaloids-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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