Mast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSchool of Dentistry-
Autor(es): dc.contributorUniversidade Federal do Rio de Janeiro (UFRJ)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.creatorFlores, Isadora Luana-
Autor(es): dc.creatorArruda, José Alcides Almeida DE-
Autor(es): dc.creatorAbrantes, Thamiris de Castro-
Autor(es): dc.creatorGamba, Thiago de Oliveira-
Autor(es): dc.creatorABRAHÃO, Aline Correa-
Autor(es): dc.creatorAnbinder, Ana Lia-
Autor(es): dc.creatorRibeiro, Jaqueline Lemes-
Autor(es): dc.creatorVasconcelos, Ana Carolina Uchoa-
Autor(es): dc.creatorAndrade, Bruno Augusto Benevenuto de-
Autor(es): dc.creatorAguiar, Maria Cassia Ferreira de-
Autor(es): dc.creatorGomes, Ana Paula Neutzling-
Autor(es): dc.creatorAbreu, Lucas Guimarães-
Autor(es): dc.creatorMesquita, Ricardo Alves-
Data de aceite: dc.date.accessioned2025-08-21T22:44:04Z-
Data de disponibilização: dc.date.available2025-08-21T22:44:04Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1807-3107bor-2024.vol38.0113-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305786-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305786-
Descrição: dc.descriptionThere is an interaction between dendrocytes and mast cells in the skin. However, in elastosis-related diseases such as actinic cheilitis (AC) and lower lip squamous cell carcinoma (LLSCC), this interaction remains unknown. We investigated the presence of intact and degranulated mast cells in AC and LLSCC. Associations of mast cells with factor XIIIa+ dendrocytes and inflammatory infiltrate were assessed. Forty cases of AC (20 with low-grade and 20 with high-grade epithelial dysplasia), 50 cases of LLSCC, and 10 cases of normal oral mucosa were evaluated. Toluidine blue staining was performed to identify mast cells, and mast cell densities were calculated in the inflammatory infiltrate. Factor XIIIa+ dendrocytes were immunohistochemically quantified. The highest ratio of intact/degranulated mast cells density was detected in LLSCC (5.9 cells/mm2), followed by AC with high-grade epithelial dysplasia (4.8 cells/mm2). Statistically significant differences were found in the density of intact mast cells compared to degranulated mast cells in AC with low-grade epithelial dysplasia (p<0.001), AC with high-grade epithelial dysplasia (p=0.005), and LLSCC (p<0.001). A positive correlation between degranulated mast cells and total inflammatory infiltrate (p=0.03) was observed in the LLSCC group. The expression of factor XIIIa+ dendrocytes was highest in AC with low-grade epithelial dysplasia (16.5 cells/mm2). The link between mast cell density, factor XIIIa+ dendrocytes, and inflammatory infiltrate indicates a potential crosstalk in lip carcinogenesis.-
Descrição: dc.descriptionUniversidade Federal do Rio Grande do Sul – UFRGS School of Dentistry Department of Oral Pathology, RS-
Descrição: dc.descriptionUniversidade Federal do Rio de Janeiro – UFRJ School of Dentistry Department of Oral Diagnosis and Pathology, RJ-
Descrição: dc.descriptionUniversidade Federal do Rio Grande do Sul – UFRGS School of Dentistry Department of Oral Radiology, RS-
Descrição: dc.descriptionUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Biosciences and Oral Diagnosis, SP-
Descrição: dc.descriptionUniversidade Federal de Pelotas – UFPel School of Dentistry Diagnostic Center for Oral Diseases, RS-
Descrição: dc.descriptionUniversidade Federal de Minas Gerais – UFMG School of Dentistry Department of Oral Surgery Pathology and Clinical Dentistry, MG-
Descrição: dc.descriptionUniversidade Federal de Minas Gerais – UFMG School of Dentistry Department of Child and Adolescent Oral Health, MG-
Descrição: dc.descriptionUniversidade Estadual Paulista – Unesp Institute of Science and Technology Department of Biosciences and Oral Diagnosis, SP-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Oral Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarcinoma, Squamous Cell-
Palavras-chave: dc.subjectCell Degranulation-
Palavras-chave: dc.subjectFactor XIIIa-
Palavras-chave: dc.subjectMast Cells-
Título: dc.titleMast cells and factor XIIIa+ dendrocytes in actinic cheilitis and lip squamous cell carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.