A Proposal for a Noxious Stimuli-Free, Moderate-Intensity Treadmill Running Protocol to Improve Aerobic Performance in Experimental Research on Rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCCS-UFRN-
Autor(es): dc.contributorAtatürk University-
Autor(es): dc.contributorYork University-
Autor(es): dc.contributorUniversity of Parma-
Autor(es): dc.creatorde Assis, Gilmara Gomes-
Autor(es): dc.creatorde Souza, Elda Olivia Nobre-
Autor(es): dc.creatorde Almeida-Neto, Paulo Francisco-
Autor(es): dc.creatorCeylan, Halil İbrahim-
Autor(es): dc.creatorBragazzi, Nicola Luigi-
Data de aceite: dc.date.accessioned2025-08-21T16:10:35Z-
Data de disponibilização: dc.date.available2025-08-21T16:10:35Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/metabo14100534-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305739-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305739-
Descrição: dc.descriptionBackground/Objectives: Animal models can help understand human physiological responses, including the response to exercise and physical activity. However, many of these models incorporate noxious stimuli for various scientific purposes. We propose a noxious stimuli-free treadmill running training program for Rattus norvegicus species to study adaptations to aerobic exercise. Methods: In this study, rats were randomly allocated to training (n = 20) and sedentary (n = 20) groups. The training group underwent a program consisting of 30–50 min of treadmill running at 60% intensity, three times per week for 8 weeks. Maximum speed tasks (Tmax) were conducted to determine, adjust, and evaluate changes in fitness conditions. The rats had one week of familiarization with the treadmill, and a rubber ball was used at the back wall of the lane as a painless stimulus to encourage running. All assessments were conducted by two independent researchers in a double-blind manner, with data analysis conducted by a third-blind investigator. Results: A significant effect of time (η2p = 0.430, p < 0.001, large effect) could be found, showing differences between Tmax1 and Tmax2, and between Tmax1 and Tmax3 in both groups. The training group significantly outperformed the sedentary group (η2p = 0.266, p < 0.001, large effect). There was a significant interaction between time and condition (η2p = 0.152, p < 0.001, large effect). Conclusions: The proposed moderate-intensity treadmill running program could effectively differentiate between trained and sedentary conditions within both the short period of 4 weeks and the extended period of 8 weeks. This protocol can be used as a model for running on a treadmill for Rattus norvegicus species without the use of noxious stimuli.-
Descrição: dc.descriptionDepartment of Odontology School of Dentistry Sao Paulo State University, SP-
Descrição: dc.descriptionHealth Sciences Center Federal University of Rio Grande do Norte CCS-UFRN, RN-
Descrição: dc.descriptionPhysical Education and Sports Teaching Department Faculty of Sports Sciences Atatürk University-
Descrição: dc.descriptionLaboratory for Industrial and Applied Mathematics (LIAM) Department of Mathematics and Statistics York University-
Descrição: dc.descriptionHuman Nutrition Unit (HNU) Department of Food and Drugs Medical School University of Parma-
Descrição: dc.descriptionDepartment of Odontology School of Dentistry Sao Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationMetabolites-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaerobic exercise-
Palavras-chave: dc.subjectanimal models-
Palavras-chave: dc.subjectanimal research-
Palavras-chave: dc.subjectfitness-
Palavras-chave: dc.subjectrat-
Palavras-chave: dc.subjecttreadmill running-
Título: dc.titleA Proposal for a Noxious Stimuli-Free, Moderate-Intensity Treadmill Running Protocol to Improve Aerobic Performance in Experimental Research on Rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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