Gellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral Candida albicans Infections

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBrown University-
Autor(es): dc.creatorGarcia, Maíra Terra-
Autor(es): dc.creatorCarmo, Paulo Henrique Fonseca do-
Autor(es): dc.creatorFigueiredo-Godoi, Lívia Mara Alves-
Autor(es): dc.creatorGonçalves, Natália Inês-
Autor(es): dc.creatorLima, Patrícia Michelle Nagai de-
Autor(es): dc.creatorRamos, Lucas de Paula-
Autor(es): dc.creatorOliveira, Luciane Dias de-
Autor(es): dc.creatorBorges, Alexandre Luiz Souto-
Autor(es): dc.creatorShukla, Anita-
Autor(es): dc.creatorJunqueira, Juliana Campos-
Data de aceite: dc.date.accessioned2025-08-21T18:04:31Z-
Data de disponibilização: dc.date.available2025-08-21T18:04:31Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16030298-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305540-
Descrição: dc.descriptionCandida albicans can cause various types of oral infections, mainly associated with denture stomatitis. Conventional therapy has been linked to high recurrence, toxicity, and fungal resistance, necessitating the search for new drugs and delivery systems. In this study, caffeic acid phenethyl ester (CAPE) and gellan gum (GG) were studied as an antifungal agent and carrier system, respectively. First, we observed that different GG formulations (0.6 to 1.0% wt/vol) were able to incorporate and release CAPE, reaching a controlled and prolonged release over 180 min at 1.0% of GG. CAPE-GG formulations exhibited antifungal activity at CAPE concentrations ranging from 128 to >512 µg/mL. Furthermore, CAPE-GG formulations significantly decreased the fungal viability of C. albicans biofilms at short times (12 h), mainly at 1.0% of GG (p < 0.001). C. albicans protease activity was also reduced after 12 h of treatment with CAPE-GG formulations (p < 0.001). Importantly, CAPE was not cytotoxic to human keratinocytes, and CAPE-GG formulations at 1.0% decreased the fungal burden (p = 0.0087) and suppressed inflammation in a rat model of denture stomatitis. Altogether, these results indicate that GG is a promising delivery system for CAPE, showing effective activity against C. albicans and potential to be used in the treatment of denture stomatitis.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionOffice of Naval Research Global-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCenter for Biomedical Engineering School of Engineering Brown University-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics Institute of Science and Technology São Paulo State University (UNESP), SP-
Descrição: dc.descriptionCNPq: CNPq 310265/2022-3-
Descrição: dc.descriptionOffice of Naval Research Global: N62909-20-1-2034-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectcaffeic acid phenethyl ester-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectdenture stomatitis-
Palavras-chave: dc.subjectgellan gum-
Palavras-chave: dc.subjectoral candidiasis-
Título: dc.titleGellan-Based Hydrogel as a Drug Delivery System for Caffeic Acid Phenethyl Ester in the Treatment of Oral Candida albicans Infections-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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