Effects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorVietnam Academy of Science and Technology-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSartori, Arthur Alves-
Autor(es): dc.creatorSon, Ninh The-
Autor(es): dc.creatorda Silva Honorio, Mariana-
Autor(es): dc.creatorRipari, Nicolas-
Autor(es): dc.creatorSantiago, Karina Basso-
Autor(es): dc.creatorGomes, Anderson Moreira-
Autor(es): dc.creatorZambuzzi, Willian Fernando-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorSforcin, José Maurício-
Data de aceite: dc.date.accessioned2025-08-21T16:19:19Z-
Data de disponibilização: dc.date.available2025-08-21T16:19:19Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-01-29-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jep.2023.117297-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305528-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305528-
Descrição: dc.descriptionEthnopharmacological relevance: Propolis is a bee product used in folk medicine to treat inflammatory diseases. Diverse types of propolis are produced worldwide depending on the local flora. Recently, research has been focused on a propolis sample produced in the northeast Brazilian “caatinga” from Mimosa tenuiflora, popularly known as “jurema-preta”. Aim of the study: A possible immunomodulatory/anti-inflammatory action was analyzed to verify the potential of M. tenuiflora propolis (MP) and its constituents (santin, sakuranetin and kaempferide) in human immune cells under baseline conditions or in LPS-stimulated cells. Methods: Cell viability, cytokine (TNF-α, IL-1β, IL-6, IL-8, IL-10) production and intracellular pathways (NF-kB and p38 MAPK) were evaluated. Results: Under basal conditions, MP and sakuranetin did not affect cytokine production; santin enhanced TNF-α, IL-1β, IL-6, while kaempferide inhibited IL-8 and IL-10. In LPS-stimulated cells, MP and its compounds exerted an inhibitory activity on TNF-α and IL-1β, while no effects were seen on IL-6 and IL-8. Santin and kaempferide inhibited IL-10 production. No significant differences were seen on NF-kB and p38 MAPK intracellular pathways. Conclusion: Data indicated the immunomodulatory action of caatinga propolis and its constituents at noncytotoxic concentrations, specifically an anti-inflammatory activity in LPS-treated cells by inhibiting cytokine production. Santin, sakuranetin and kaempferide appeared to be involved in MP activities.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences, SP-
Descrição: dc.descriptionInstitute of Chemistry Vietnam Academy of Science and Technology, 18 Hoàng Quoc Viet, Cầu giay-
Descrição: dc.descriptionUniversity of São Paulo (USP) School of Pharmaceutical Sciences of Ribeirão Preto, SP-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Biosciences, SP-
Descrição: dc.descriptionFAPESP: 2017/04138-8-
Idioma: dc.languageen-
Relação: dc.relationJournal of Ethnopharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCaatinga-
Palavras-chave: dc.subjectImmune cells-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectIsolated constituents-
Palavras-chave: dc.subjectPropolis-
Título: dc.titleEffects of caatinga propolis from Mimosa tenuiflora and its constituents (santin, sakuranetin and kaempferide) on human immune cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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