Personalized bioceramic grafts for craniomaxillofacial bone regeneration

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Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorCleveland State University-
Autor(es): dc.contributorUniversity of Toledo-
Autor(es): dc.contributorUtrecht University-
Autor(es): dc.contributorRegenerative Medicine Center Utrecht-
Autor(es): dc.contributorUniversity Medical Center Utrecht-
Autor(es): dc.creatorde Carvalho, Ana Beatriz G.-
Autor(es): dc.creatorRahimnejad, Maedeh-
Autor(es): dc.creatorOliveira, Rodrigo L. M. S.-
Autor(es): dc.creatorSikder, Prabaha-
Autor(es): dc.creatorSaavedra, Guilherme S. F. A.-
Autor(es): dc.creatorBhaduri, Sarit B.-
Autor(es): dc.creatorGawlitta, Debby-
Autor(es): dc.creatorMalda, Jos-
Autor(es): dc.creatorKaigler, Darnell-
Autor(es): dc.creatorTrichês, Eliandra S.-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2025-08-21T21:39:56Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:56Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41368-024-00327-7-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305475-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305475-
Descrição: dc.descriptionThe reconstruction of craniomaxillofacial bone defects remains clinically challenging. To date, autogenous grafts are considered the gold standard but present critical drawbacks. These shortcomings have driven recent research on craniomaxillofacial bone reconstruction to focus on synthetic grafts with distinct materials and fabrication techniques. Among the various fabrication methods, additive manufacturing (AM) has shown significant clinical potential. AM technologies build three-dimensional (3D) objects with personalized geometry customizable from a computer-aided design. These layer-by-layer 3D biomaterial structures can support bone formation by guiding cell migration/proliferation, osteogenesis, and angiogenesis. Additionally, these structures can be engineered to degrade concomitantly with the new bone tissue formation, making them ideal as synthetic grafts. This review delves into the key advances of bioceramic grafts/scaffolds obtained by 3D printing for personalized craniomaxillofacial bone reconstruction. In this regard, clinically relevant topics such as ceramic-based biomaterials, graft/scaffold characteristics (macro/micro-features), material extrusion-based 3D printing, and the step-by-step workflow to engineer personalized bioceramic grafts are discussed. Importantly, in vitro models are highlighted in conjunction with a thorough examination of the signaling pathways reported when investigating these bioceramics and their effect on cellular response/behavior. Lastly, we summarize the clinical potential and translation opportunities of personalized bioceramics for craniomaxillofacial bone regeneration.-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University, SP-
Descrição: dc.descriptionFederal University of São Paulo Institute of Science and Technology, SP-
Descrição: dc.descriptionDepartment of Mechanical Engineering Cleveland State University-
Descrição: dc.descriptionDepartment of Mechanical Industrial and Manufacturing Engineering University of Toledo-
Descrição: dc.descriptionDepartment of Oral and Maxillofacial Surgery & amp; Special Dental Care University Medical Center Utrecht Utrecht University-
Descrição: dc.descriptionRegenerative Medicine Center Utrecht-
Descrição: dc.descriptionDepartment of Clinical Sciences Faculty of Veterinary Medicine Utrecht University-
Descrição: dc.descriptionDepartment of Orthopedics University Medical Center Utrecht-
Descrição: dc.descriptionDepartment of Periodontics and Oral Medicine School of Dentistry University of Michigan-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics São Paulo State University, SP-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Oral Science-
???dc.source???: dc.sourceScopus-
Título: dc.titlePersonalized bioceramic grafts for craniomaxillofacial bone regeneration-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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