Development and Evaluation of the Acaricidal Activity of Xantan Gum-Based Hydrogel and Polymeric Nanoparticles Containing Achyrocline satureioides Extract

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversity of Valencia-
Autor(es): dc.creatorFantatto, Rafaela Regina-
Autor(es): dc.creatorGomes, Annelize Rodrigues-
Autor(es): dc.creatorConstantini, João Vitor Carvalho-
Autor(es): dc.creatorRodero, Camila Fernanda-
Autor(es): dc.creatorChorilli, Marlus-
Autor(es): dc.creatorChagas, Ana Carolina de Souza-
Autor(es): dc.creatorMelero, Ana-
Autor(es): dc.creatorPietro, Rosemeire Cristina Linhari Rodrigues-
Data de aceite: dc.date.accessioned2025-08-21T15:36:02Z-
Data de disponibilização: dc.date.available2025-08-21T15:36:02Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/gels10100658-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305457-
Descrição: dc.descriptionThe Rhipicephalus microplus tick causes enormous economic losses in livestock farming around the world. Despite several promising studies carried out with plant extracts such as Achyrocline satureioides against this ectoparasite, a major obstacle is related to pharmaceutical presentation forms. There is no study showing xantan gum-based hydrogel and polycaprolactone nanoparticles containing A. satureioides extract against R. microplus larvae. The objective of this study was to incorporate A. satureioides extract to develop a nanoformulation (AScn) and a hydrogel (ASlh) and evaluate them against R. microplus larvae with the purpose of increasing the contact time of the extract with the larvae and improve the effectiveness. The ethanolic extracts were incorporated in polycaprolactone nanoparticles and characterized via analysis of the mean hydrodinamic diameter and polidispersity index. The xanthan gum-based hydrogel formulation was prepared with crude extract of A. satureioides 40 mg/mL, 0.25% xanthan gum, and 8% poloxamer, to determine the bioadhesiveness of the formulation in bovine leather and the flow rate of the formulation in the animal. The results in larvae demonstrated that when evaluated in the form of a hydrogel (ASlh), mortality was higher, with 91.48% mortality at a concentration of 20 mg/mL presenting itself as an interesting alternative for controlling this ectoparasite.-
Descrição: dc.descriptionDepartament of Drugs and Medicines São Paulo State University UNESP, Rodovia Araraquara-Jaú Km 1-
Descrição: dc.descriptionSoutheast Livestock Unit EMBRAPA-Brazilian Agricultural Research Corporation-
Descrição: dc.descriptionDepartment of Pharmacy and Pharmaceutical Technology and Parasitology Faculty of Pharmacy University of Valencia, Avda. Vincent Andrés Estellés s/n-
Descrição: dc.descriptionDepartament of Drugs and Medicines São Paulo State University UNESP, Rodovia Araraquara-Jaú Km 1-
Idioma: dc.languageen-
Relação: dc.relationGels-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectacaricidal activity-
Palavras-chave: dc.subjectAchyrocline satureioides-
Palavras-chave: dc.subjecthydrogel-
Palavras-chave: dc.subjectRhipicephalus microplus-
Palavras-chave: dc.subjectxanthan gum-
Título: dc.titleDevelopment and Evaluation of the Acaricidal Activity of Xantan Gum-Based Hydrogel and Polymeric Nanoparticles Containing Achyrocline satureioides Extract-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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