Enhanced mechanical strength and bioactivity of 3D-printed β-TCP scaffolds coated with bioactive glasses

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal Institute of São Paulo (IFSP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPlasmas and Processes Laboratory-
Autor(es): dc.creatorBezerra Melo, Márcia Cristina-
Autor(es): dc.creatorSpirandeli, Bruno Roberto-
Autor(es): dc.creatorBarbosa, Lucas-
Autor(es): dc.creatorRibeiro dos Santos, Verônica-
Autor(es): dc.creatorBastos de Campos, Tiago Moreira-
Autor(es): dc.creatorThim, Gilmar Patrocínio-
Autor(es): dc.creatorde Sousa Trichês, Eliandra-
Data de aceite: dc.date.accessioned2025-08-21T16:36:58Z-
Data de disponibilização: dc.date.available2025-08-21T16:36:58Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jmbbm.2024.106850-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305449-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305449-
Descrição: dc.description3D printing in scaffold production offers a promising approach, enabling precise architectural design that closely mimics the porosity and interconnectivity of natural bone. β-Tricalcium phosphate (β-Ca₃(PO₄)₂, β-TCP), with a chemical composition similar to the inorganic component of bone, is a widely used material for scaffold fabrication. Recent advances have made it possible to functionalize ceramic scaffolds to improve bone regeneration and repair while enabling the in situ release of therapeutic agents to treat bone infections. In this study, 3D-printed β-TCP scaffolds were coated with bioactive glasses, 45S5 (45SiO₂ – 24.5Na₂O – 24.5CaO – 6P₂O₅, wt.%) and 58S (58SiO₂ – 33CaO – 9P₂O₅, wt.%), using sol-gel solutions through a vacuum impregnation technique. The β-TCP ink exhibited pseudoplastic behavior, which facilitated its 3D printing. The resulting scaffolds demonstrated high fidelity to the designed model, featuring well-aligned filaments and minimal collapse of the lower layers after sintering. Elemental mapping revealed that 45S5 glass formed a surface coating around the scaffold struts, whereas 58S glass penetrated the internal structure, this occurred due to their differing viscosities at high temperatures. Compared to uncoated β-TCP scaffolds, the coatings significantly improved mechanical strength, with increases of 63% and 126% for scaffolds coated with 45S5 and 58S, respectively. Bioactivity was confirmed through an apatite mineralization assay in simulated body fluid, which demonstrated hydroxyapatite precipitation on both coated scaffolds, albeit with distinct morphologies. Since this study focused on acellular scaffolds, further research is necessary to fully explore the potential of these bioactive scaffolds with optimized mechanical properties in biological systems.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFederal University of São Paulo Institute of Science and Technology Bioceramics Laboratory, 330 Talim St, SP-
Descrição: dc.descriptionFederal Institute of São Paulo (IFSP), São Paulo-
Descrição: dc.descriptionSao Paulo State University Institute of Science and Technology Department of Bioscience and Buccal Diagnose, SP-
Descrição: dc.descriptionUniversity of São Paulo Bauru School of Dentistry Department of Prosthodontics and Periodontology, SP-
Descrição: dc.descriptionAeronautic Technological Institute Plasmas and Processes Laboratory, SP-
Descrição: dc.descriptionSao Paulo State University Institute of Science and Technology Department of Bioscience and Buccal Diagnose, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of the Mechanical Behavior of Biomedical Materials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject3D printing-
Palavras-chave: dc.subject45S5-
Palavras-chave: dc.subject58S-
Palavras-chave: dc.subjectBioactive glasses-
Palavras-chave: dc.subjectCoating-
Palavras-chave: dc.subjectScaffolds-
Palavras-chave: dc.subjectβ-tricalcium phosphate-
Título: dc.titleEnhanced mechanical strength and bioactivity of 3D-printed β-TCP scaffolds coated with bioactive glasses-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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