Effects of Baccharis dracunculifolia DC on an Innovative Animal Model of Cardiometabolic Syndrome

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Autor(es): dc.contributorParanaense University-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilva, Gustavo Ratti da-
Autor(es): dc.creatorKluck, Arianne Jung-
Autor(es): dc.creatorAlbuquerque, Edilson Rodrigues-
Autor(es): dc.creatorGuarnier, Lucas Pires-
Autor(es): dc.creatorBraga, Fernanda de Abreu-
Autor(es): dc.creatorSilva, Ester Pelegrini-
Autor(es): dc.creatorNegrini, Karina Sposito-
Autor(es): dc.creatorMendonça, Juliana Aparecida-
Autor(es): dc.creatorGazim, Zilda Cristiani-
Autor(es): dc.creatorGasparotto Junior, Arquimedes-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu-
Autor(es): dc.creatorLívero, Francislaine Aparecida dos Reis-
Data de aceite: dc.date.accessioned2025-08-21T20:38:17Z-
Data de disponibilização: dc.date.available2025-08-21T20:38:17Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/pharmaceutics16111446-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305379-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305379-
Descrição: dc.descriptionBackground/Objective: Cardiometabolic syndrome (CMS) is a complex clinical condition that encompasses metabolic dysregulation, cardiovascular disease, and diabetes risk factors. Worldwide, CMS is underdiagnosed, and its occurrence significantly increases cardiovascular morbimortality. Despite available pharmacological treatments, the approach is fragmented, and the associated clinical conditions are treated independently. This approach may be partially due to limited preclinical models to mimic the clinical conditions of CMS. Therefore, our study aims to present an innovative animal model of cardiometabolic syndrome and evaluate the effects of Baccharis dracunculifolia on the set of clinical alterations associated with the condition. Methods: Female Wistar rats were induced to develop diabetes, fed a cholesterol-enriched diet, and exposed to the smoke of 9 cigarettes/day for 6 weeks. During the last 2 weeks, the rats were treated with vehicle, B. dracunculifolia (30, 100, and 300 mg/kg), or a combination of simvastatin and insulin. At the end of the treatment, plasma lipid levels were measured, and the liver was analyzed histologically for hepatic lipid quantification and oxidative stress assessment. Results: Phytochemical analysis revealed seven phenolic acids and six flavonoids in the extract. B. dracunculifolia showed significant hepatoprotective effects, reducing AST and ALT levels and lowering both plasma and hepatic lipid levels. The extract also reversed hepatic steatosis and demonstrated antioxidant properties. Conclusions: These findings suggest that B. dracunculifolia may be a therapeutic option for the metabolic dysregulation present in CMS.-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Post-Graduate Program in Animal Science with Emphasis on Bioactive Products Paranaense University-
Descrição: dc.descriptionLaboratory of Cardiometabolic Pharmacology Federal University of Paraná (UFPR), Curitiba-
Descrição: dc.descriptionDepartment of Genetic Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Post-Graduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention Paranaense University-
Descrição: dc.descriptionChemistry Laboratory of Natural Products Post-Graduate Program in Biotechnology Applied to Agriculture Paranaense University-
Descrição: dc.descriptionChemistry Laboratory of Natural Products Post-Graduate Programs in Animal Science and Biotechnology Applied to Agriculture Paranaense University-
Descrição: dc.descriptionLaboratory of Cardiovascular Pharmacology Faculty of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy (GenTe Cel) Department of Biotechnology São Paulo State University-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy (GenTe Cel) Department of Biotechnology São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationPharmaceutics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalecrim-do-campo-
Palavras-chave: dc.subjectdiabetes-
Palavras-chave: dc.subjectdyslipidemia-
Palavras-chave: dc.subjectmetabolic syndrome-
Palavras-chave: dc.subjectpreclinical study-
Palavras-chave: dc.subjectsmoking-
Palavras-chave: dc.subjecttraditional medicine-
Título: dc.titleEffects of Baccharis dracunculifolia DC on an Innovative Animal Model of Cardiometabolic Syndrome-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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