Metabolic Alterations in Canine Mammary Tumors

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorSão José do Rio Preto Faculty of Medicine-
Autor(es): dc.contributorBrazilian Center for Research in Energy and Materials (CNPEM)-
Autor(es): dc.contributorMato Grosso Federal University (UFMT)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTamarindo, Guilherme Henrique-
Autor(es): dc.creatorNovais, Adriana Alonso-
Autor(es): dc.creatorChuffa, Luiz Gustavo Almeida-
Autor(es): dc.creatorZuccari, Debora Aparecida Pires Campos-
Data de aceite: dc.date.accessioned2025-08-21T23:17:57Z-
Data de disponibilização: dc.date.available2025-08-21T23:17:57Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ani13172757-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305330-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305330-
Descrição: dc.descriptionCanine mammary tumors (CMTs) are among the most common diseases in female dogs and share similarities with human breast cancer, which makes these animals a model for comparative oncology studies. In these tumors, metabolic reprogramming is known as a hallmark of carcinogenesis whereby cells undergo adjustments to meet the high bioenergetic and biosynthetic demands of rapidly proliferating cells. However, such alterations are also vulnerabilities that may serve as a therapeutic strategy, which has mostly been tested in human clinical trials but is poorly explored in CMTs. In this dedicated review, we compiled the metabolic changes described for CMTs, emphasizing the metabolism of carbohydrates, amino acids, lipids, and mitochondrial functions. We observed key factors associated with the presence and aggressiveness of CMTs, such as an increase in glucose uptake followed by enhanced anaerobic glycolysis via the upregulation of glycolytic enzymes, changes in glutamine catabolism due to the overexpression of glutaminases, increased fatty acid oxidation, and distinct effects depending on lipid saturation, in addition to mitochondrial DNA, which is a hotspot for mutations. Therefore, more attention should be paid to this topic given that targeting metabolic fragilities could improve the outcome of CMTs.-
Descrição: dc.descriptionDepartment of Molecular Biology São José do Rio Preto Faculty of Medicine, SP-
Descrição: dc.descriptionBrazilian Biosciences National Laboratory Brazilian Center for Research in Energy and Materials (CNPEM), SP-
Descrição: dc.descriptionHealth Sciences Institute (ICS) Mato Grosso Federal University (UFMT), MT-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences São Paulo State University (UNESP), SP-
Idioma: dc.languageen-
Relação: dc.relationAnimals-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectamino acids-
Palavras-chave: dc.subjectcancer-
Palavras-chave: dc.subjectcanine mammary tumors-
Palavras-chave: dc.subjectglucose-
Palavras-chave: dc.subjectlipids-
Palavras-chave: dc.subjectmetabolic reprogramming-
Palavras-chave: dc.subjectmetabolism-
Palavras-chave: dc.subjectmitochondria-
Título: dc.titleMetabolic Alterations in Canine Mammary Tumors-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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