Fibrous-biocomposites scaffold of natural rubber with bioactive glass–ceramic particles obtained by solution blowing spinning

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFHO-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorFederal Institute of Maranhão - IFMA-
Autor(es): dc.contributorUniversidade Estadual de Maringá (UEM)-
Autor(es): dc.contributorUniversity of Illinois at Chicago (UIC)-
Autor(es): dc.creatorLima, Luiz Rogério Monteiro-
Autor(es): dc.creatorVilches, José Luiz-
Autor(es): dc.creatorCaetano, Guilherme Ferreira-
Autor(es): dc.creatorSilva, Lais Dantas-
Autor(es): dc.creatorSoares, Viviane Oliveira-
Autor(es): dc.creatordos Santos, Renivaldo José-
Autor(es): dc.creatorSanches, Alex Otávio-
Autor(es): dc.creatorMalmonge, José Antônio-
Autor(es): dc.creatorYarin, Alexander L.-
Autor(es): dc.creatorSilva, Michael Jones-
Data de aceite: dc.date.accessioned2025-08-21T19:08:41Z-
Data de disponibilização: dc.date.available2025-08-21T19:08:41Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2025-03-10-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/app.56448-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305316-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305316-
Descrição: dc.descriptionBioactive glass-ceramics (BGs) are widely used in clinical applications due to their excellent biodynamic and biological properties, though their low mechanical strength limits their use in load-bearing contexts. This study aimed to develop fibrous biocomposite scaffolds based on natural rubber (NR) reinforced with BG particles, such as biosilicato (BioS) and 45S5-K (BL0), to improve tensile strength, biocompatibility, and bioactivity for biomedical applications, such as tissue engineering. Morphological, tensile, thermal, and biological tests were conducted to evaluate the impact of BG particles on the NR fibrous matrix. TG/DTG analysis revealed similar decomposition profiles for NR/BioS and NR/BL0 biocomposites compared to NR mats, with primary degradation occurring in the 290–450°C range. Tensile tests demonstrated that the addition of 30 mass% BioS or BL0 enhanced the ultimate tensile strength (σbreak) of the NR matrix from 1.44 ± 0.08 to 3.38 ± 1.31 MPa (NR/BioS) and 1.97 ± 0.53 MPa (NR/BL0). The Cole–Cole plot indicated system heterogeneity and strong NR-BG particle interactions. Cytotoxicity tests revealed over 70% MSC viability for NR, NR/BioS, and NR/BL0 biocomposites, meeting ISO 10993-5:2009 standards. These findings suggest that incorporating BioS and BL0 enhances the mechanical and biological properties of NR-based scaffolds, making them suitable for biomedical applications, such as bone regeneration.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionGraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation FHO, São Paulo-
Descrição: dc.descriptionDivision of Dermatology Department of Internal Medicine Ribeirão Preto Medical School University of São Paulo, São Paulo-
Descrição: dc.descriptionPostgraduate Program in Materials Engineering Federal Institute of Maranhão - IFMA, São Luis-
Descrição: dc.descriptionDepartment of Sciences Regional Campus of Goioerê State University of Maringá (UEM), Paraná-
Descrição: dc.descriptionDepartment of Engineering School of Engineering and Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Mechanical and Industrial Engineering University of Illinois at Chicago (UIC)-
Descrição: dc.descriptionDepartment of Physics and Chemistry School of Engineering São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionDepartment of Engineering School of Engineering and Science São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionFAPESP: 2021/1051-5-
Idioma: dc.languageen-
Relação: dc.relationJournal of Applied Polymer Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiomaterials-
Palavras-chave: dc.subjectbiomedical applications-
Palavras-chave: dc.subjectbiopolymers and renewable polymers-
Palavras-chave: dc.subjectcomposites-
Palavras-chave: dc.subjectrubber-
Título: dc.titleFibrous-biocomposites scaffold of natural rubber with bioactive glass–ceramic particles obtained by solution blowing spinning-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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