Bimodal distribution of azole susceptibility in Sporothrix brasiliensis isolates in Brazil

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorOak Ridge Institute for Science and Education-
Autor(es): dc.contributorCenters for Disease Control and Prevention-
Autor(es): dc.contributorUniversidade Federal de Mato Grosso do Sul (UFMS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstituto Adolfo Lutz-
Autor(es): dc.contributorSecretary of Health-
Autor(es): dc.contributorGrupo Fleury-
Autor(es): dc.creatorDos Santos, Amanda Ribeiro-
Autor(es): dc.creatorGade, Lalitha-
Autor(es): dc.creatorMisas, Elizabeth-
Autor(es): dc.creatorLitvintseva, Anastasia P.-
Autor(es): dc.creatorNunnally, Natalie S.-
Autor(es): dc.creatorParnell, Lindsay A.-
Autor(es): dc.creatorRajeev, Malavika-
Autor(es): dc.creatorDe Souza Carvalho Melhem, Marcia-
Autor(es): dc.creatorTakahashi, Juliana Possato Fernandes-
Autor(es): dc.creatorOliboni, Gabriel Manzi-
Autor(es): dc.creatorBonfieti, Lucas Xavier-
Autor(es): dc.creatorAraujo, Lisandra Siufi-
Autor(es): dc.creatorCappellano, Paola-
Autor(es): dc.creatorVenturini, James-
Autor(es): dc.creatorLockhart, Shawn R.-
Autor(es): dc.creatorSexton, D. Joseph-
Data de aceite: dc.date.accessioned2025-08-21T19:38:21Z-
Data de disponibilização: dc.date.available2025-08-21T19:38:21Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2024-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1128/aac.01620-23-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305245-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305245-
Descrição: dc.descriptionSporothrix brasiliensis is an emerging zoonotic fungal pathogen that can be difficult to treat. Antifungal susceptibility testing was performed on the mold phase of a convenience sample of 61 Sporothrix spp. isolates from human and cat sporotrichosis cases in Brazil using the Clinical and Laboratory Standards Institute standard M38. A bimodal distribution of azole susceptibility was observed with 50% (28/56) of S. brasiliensis isolates showing elevated itraconazole minimum inhibitory concentrations ≥16 μg/mL. Phylogenetic analysis found the in vitro resistant isolates were not clonal and were distributed across three different S. brasiliensis clades. Single nucleotide polymorphism (SNP) analysis was performed to identify potential mechanisms of in vitro resistance. Two of the 28 resistant isolates (MIC ≥16 mg/L) had a polymorphism in the cytochrome P450 gene, cyp51, corresponding to the well-known G448S substitution inducing azole resistance in Aspergillus fumigatus. SNPs corresponding to other known mechanisms of azole resistance were not identified in the remaining 26 in vitro resistant isolates.-
Descrição: dc.descriptionOak Ridge Institute for Science and Education-
Descrição: dc.descriptionMycotic Diseases Branch Centers for Disease Control and Prevention-
Descrição: dc.descriptionSchool of Medicine Universidade Federal de Mato Grosso Do Sul, MS-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Universidade Estadual Paulista, SP-
Descrição: dc.descriptionParasitology and Mycology Center Instituto Adolfo Lutz, SP-
Descrição: dc.descriptionGraduate Program in Sciences Coordenadoria de Controle de Doenças Secretary of Health-
Descrição: dc.descriptionCentral Public Health Laboratory of Mato Grosso Do Sul Secretary of Health, MS-
Descrição: dc.descriptionMicrobiology Section Grupo Fleury, SP-
Descrição: dc.descriptionGraduate Program in Tropical Diseases Universidade Estadual Paulista, SP-
Idioma: dc.languageen-
Relação: dc.relationAntimicrobial Agents and Chemotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal agents-
Palavras-chave: dc.subjectantifungal resistance-
Palavras-chave: dc.subjectsporotrichosis-
Título: dc.titleBimodal distribution of azole susceptibility in Sporothrix brasiliensis isolates in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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