The Resolution of Periodontal Inflammation Promotes Changes in Cytokine Expression in the Intestine and Gingival Tissues of Aged Rats with DSS-Induced Colitis

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Autor(es): dc.contributorJames Cook University-
Autor(es): dc.contributorGriffith University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorKarolinska Institutet-
Autor(es): dc.creatorde Mello-Neto, João Martins-
Autor(es): dc.creatorErvolino, Edilson-
Autor(es): dc.creatorElangovan, Gayathiri-
Autor(es): dc.creatorToro, Luan Felipe-
Autor(es): dc.creatorLee, Jaehee-
Autor(es): dc.creatorGustafsson, Anders-
Autor(es): dc.creatorFigueredo, Carlos Marcelo da Silva-
Data de aceite: dc.date.accessioned2025-08-21T18:43:36Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:36Z-
Data de envio: dc.date.issued2025-04-29-
Data de envio: dc.date.issued2023-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/jcm12134326-
Fonte completa do material: dc.identifierhttps://hdl.handle.net/11449/305226-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/305226-
Descrição: dc.descriptionOur research aimed to explore how resolving periodontal inflammation impacts cytokine expression in the colons of aged Wistar rats. Research studies involving animals have been conducted to investigate the two-way relationship between periodontitis and inflammatory bowel disease (IBD), where chronic inflammation in either the mouth or intestines can negatively affect the other. We allocated seventeen male Wistar rats aged between 8 and 11 months to one of four groups: (1) ligature-induced periodontitis (LIP) without the resolution of periodontal inflammation (RPI) (LIP; n = 4), (2) LIP + RPI (n = 4), (3) LIP + dextran-sulphate-sodium-induced colitis (DIC) without RPI (n = 4), and LIP + DIC + RPI (n = 5). We performed histopathological and immunological analyses on periodontal and intestinal tissues and analysed cytokine expressions using a Rat Cytokine 23-Plex Immunoassay. Our findings showed that animals with and without DIC who underwent RPI showed significantly lower levels of IL-2, IL-4, IL-5, IL-10, IL-13, IL-17, IL-18, and TNF-α in the intestine compared to those without treatment. The RPI effectively reduced the number of inflammatory cells in the lamina propria and restored the epithelial barrier in the intestine in animals with DIC. The resolution of periodontal inflammation significantly reduced the levels of pro-inflammatory cytokines and chemokines in the intestines of aged rats with and without DSS-induced colitis.-
Descrição: dc.descriptionCollege of Medicine and Dentistry James Cook University-
Descrição: dc.descriptionSchool of Medicine and Dentistry Griffith University-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University-UNESP, SP-
Descrição: dc.descriptionDivision of Oral Diseases Department of Dental Medicine Karolinska Institutet-
Descrição: dc.descriptionDepartment of Basic Sciences School of Dentistry São Paulo State University-UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Clinical Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytokines-
Palavras-chave: dc.subjectdextran sulphate sodium-
Palavras-chave: dc.subjectinflammatory bowel diseases-
Palavras-chave: dc.subjectintestine-
Palavras-chave: dc.subjectperiodontitis-
Palavras-chave: dc.subjectrats-
Título: dc.titleThe Resolution of Periodontal Inflammation Promotes Changes in Cytokine Expression in the Intestine and Gingival Tissues of Aged Rats with DSS-Induced Colitis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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